{{Rsnum
|rsid=921451
|Gene=DDC
|Chromosome=7
|position=50555587
|Orientation=plus
|GMAF=0.3384
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=DDC
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 15.0 | 40.7 | 44.2
| HCB | 28.5 | 44.5 | 27.0
| JPT | 23.0 | 50.4 | 26.5
| YRI | 2.1 | 33.3 | 64.6
| ASW | 3.5 | 35.1 | 61.4
| CHB | 28.5 | 44.5 | 27.0
| CHD | 32.1 | 45.0 | 22.9
| GIH | 20.8 | 47.5 | 31.7
| LWK | 3.6 | 31.8 | 64.5
| MEX | 1.7 | 37.9 | 60.3
| MKK | 6.4 | 36.5 | 57.1
| TSI | 12.7 | 41.2 | 46.1
| HapMapRevision=28
}}
per OMIM, Ma et al. (2005) {{PMID|15879433}} found two different DDC haplotypes associated with nicotine dependence in African Americans and European Americans (with measures of smoking quantity [SQ], heaviness of [[smoking]] index [HSI], and the Fagerstrom test for ND [FTND])
*in African Americans, [[rs921451]](T), [[rs3735273]](G), [[rs1451371]](T), [[rs2060762]](G), all three measures sig. associated after correction for multiple testing
*in European Americans, [[rs921451]](T), [[rs3735273]](G), [[rs1451371]](T), [[rs3757472]](G), which showed a sig. assoc. w/ the SQ and FTND score

{{omim
|desc=TOBACCO [[Addiction]], SUSCEPTIBILITY TO
|id=188890
|rsnum=921451
}}

{{omim
|desc=DOPA DECARBOXYLASE; DDC
|id=107930
|rsnum=921451
}}

{{PharmGKB
|RSID=rs921451
|Name_s=
|Gene_s=DDC
|Feature=
|Evidence=PubMed ID:15879433
|Annotation=In a total of 2037 smokers and non-smokers from 602 nuclear families of African- or European-American ancestry, this SNP in the DDC gene was significantly associated with two of the three adjusted nicotine dependence measures in the European-American sample. Further the variant is part of two haplotypes, a protective T-G-T-G haplotype for rs921451-rs3735273-rs1451371-rs2060762 in the African-American sample and a high-risk T-G-T-G haplotype for rs921451-rs3735273-rs1451371-rs3757472 in the European-American sample.
|Drugs=nicotine
|Drug Classes=
|Diseases=Tobacco Use Disorder
|Curation Level=Curated
|PharmGKB Accession ID=PA162316615
}}

{{PMID Auto
|PMID=17184203
|Title=DOPA decarboxylase gene is associated with nicotine dependence.
}}

{{PMID Auto
|PMID=19184136
|Title=Examination of association of genes in the serotonin system to autism.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs921451
|overall_frequency_n=36
|overall_frequency_d=126
|overall_frequency=0.285714
|n_genomes=24
|n_genomes_annotated=0
|n_haplomes=29
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Illumina Human 1M}}