{{Rsnum
|rsid=925946
|Gene=BDNFOS
|Chromosome=11
|position=27645655
|Orientation=plus
|GMAF=0.2282
|Gene_s=BDNF-AS
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 48.7 | 38.1 | 13.3
| HCB | 93.4 | 6.6 | 0.0
| JPT | 87.6 | 12.4 | 0.0
| YRI | 49.0 | 42.9 | 8.2
| ASW | 50.9 | 40.4 | 8.8
| CHB | 93.4 | 6.6 | 0.0
| CHD | 98.2 | 1.8 | 0.0
| GIH | 38.6 | 48.5 | 12.9
| LWK | 39.1 | 40.0 | 20.9
| MEX | 58.6 | 37.9 | 3.4
| MKK | 47.7 | 43.2 | 9.0
| TSI | 61.8 | 33.3 | 4.9
| HapMapRevision=28
}}
{{PMID Auto GWAS
|PMID=19079260
|Trait=Body mass index
|Title=Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
|RiskAllele=T
|Pval=9E-10
|OR=3.85
|ORtxt=[2.62-5.08] % SD
}}

{{PharmGKB
|RSID=rs925946
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19079260; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. (Initial Sample Size: 80,969 individuals; Replication Sample Size: 11,036 individuals); (Region: 11p14.1; Reported Gene(s): BDNF; Risk Allele: rs925946-T); (p-value= 0.000000004).This variant is associated with Weight.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740161
}}

{{PharmGKB
|RSID=rs925946
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19079260; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. (Initial Sample Size: 80,969 individuals; Replication Sample Size: 11,036 individuals); (Region: 11p14.1; Reported Gene(s): BDNF; Risk Allele: rs925946-T); (p-value= 0.0000000009).This variant is associated with Body mass index.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740148
}}
{{PMID Auto
|PMID=21188787
|Title=Brain-derived neurotrophic factor gene polymorphisms: influence on treatment response phenotypes of major depressive disorder
}}

{{PMID Auto
|PMID=21796141
|Title=Computed tomography analysis of the association between the SH2B1 rs7498665 single-nucleotide polymorphism and visceral fat area
}}

{{PMID Auto
|PMID=21912638
|Title=Studies of metabolic phenotypic correlates of 15 obesity associated gene variants
|OA=1
}}

{{PMID Auto
|PMID=19478790
|Title=The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI.
|OA=1
}}

{{PMID Auto
|PMID=19526209
|Title=Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?
|OA=1
}}

{{PMID Auto
|PMID=19553259
|Title=Common body mass index-associated variants confer risk of extreme obesity.
|OA=1
}}

{{PMID Auto
|PMID=20520848
|Title=Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth.
|OA=1
}}

{{PMID Auto
|PMID=20712903
|Title=Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.
|OA=1
}}

{{PMID Auto
|PMID=20724581
|Title=Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies.
|OA=1
}}

{{PMID Auto
|PMID=20824172
|Title=Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk prospective population study.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs925946
|overall_frequency_n=91
|overall_frequency_d=126
|overall_frequency=0.722222
|n_genomes=50
|n_genomes_annotated=0
|n_haplomes=78
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

[[Obesity: Preliminary Research]]

{{PMID Auto
|PMID=23640704
|Title=Common variants near BDNF and SH2B1 show nominal evidence of association with snacking behavior in European populations
}}

{{PMID Auto
|PMID=23318717
|Title=Sex-specific effects of weight-affecting gene variants in a life course perspective--The HUNT Study, Norway.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}