{{Rsnum
|rsid=926103
|Gene=SH2D2A
|Chromosome=1
|position=156815190
|Orientation=minus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.382
|Gene_s=NTRK1,SH2D2A
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 47.7 | 52.3 | 0.0
| HCB | 0.8 | 24.2 | 75.0
| JPT | 4.5 | 29.5 | 66.1
| YRI | 56.7 | 39.7 | 3.5
| ASW | 33.9 | 48.2 | 17.9
| CHB | 0.8 | 24.2 | 75.0
| CHD | 4.6 | 31.5 | 63.9
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 8.6 | 53.4 | 37.9
| MKK | 22.0 | 58.7 | 19.3
| TSI | 14.1 | 49.5 | 36.4
| HapMapRevision=28
}}

[[Rs926103]] is located within the [[SH2D2A]] gene on Chromosome 1. SH2D2A encodes an adapter protein thought to function in T-cell signal transduction. {{PMID|11528519}}

A study in the Journal for Neuroimmunology reported that 16 repeats repeat of GA after the (A;A) allele at this SNP is associated with [[multiple sclerosis]] in Norwegian, Danish and Swedish sample sets. {{PMID|18554728}}

The study concludes that the SH2D2A gene may contribute to susceptibility to MS. {{PMID|18554728}}

This study has yet to be verified or reproduced in any subsequent research.

{{PMID|11528519}} The T cell regulator gene SH2D2A contributes to the genetic susceptibility of [[multiple sclerosis]]

{{PMID|18554728}} [[rs926103]] and a GA repeat polymorphism forming a risk haplotype for [[Multiple sclerosis]] 



{{interesting}}
The fact that this is a mixture of a snp and a repeat makes this an interesting test case for [[Promethease]]

{{GET Evidence
|gene=SH2D2A
|aa_change=Asn34Ser
|aa_change_short=N34S
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs926103
|n_genomes=1
|n_genomes_annotated=0
|n_haplomes=1
|n_articles=0
|n_articles_annotated=0
|nblosum100=0
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}