{{Rsnum
|rsid=9264942
|Gene=RPL3P2
|Chromosome=6
|position=31306603
|Orientation=plus
|GMAF=0.3485
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 9.7 | 48.7 | 41.6
| HCB | 15.3 | 46.0 | 38.7
| JPT | 16.8 | 46.9 | 36.3
| YRI | 5.4 | 36.7 | 57.8
| ASW | 12.3 | 47.4 | 40.4
| CHB | 15.3 | 46.0 | 38.7
| CHD | 15.6 | 48.6 | 35.8
| GIH | 27.7 | 45.5 | 26.7
| LWK | 10.0 | 42.7 | 47.3
| MEX | 19.0 | 41.4 | 39.7
| MKK | 13.5 | 43.6 | 42.9
| TSI | 9.8 | 59.8 | 30.4
| HapMapRevision=28
}}This SNP (C/T) is in 5' region of the HLA-C gene, 35 kb away from transcription initiation in or around the HLA-C gene.

"People with this tiny sequence variation, dubbed rs9264942, appear to have up to 90% less virus in their systems than those who carry other polymorphisms.
About 10% of Europeans appear to carry two copies of rs9264942, which leads to an average 90% viral load reduction. About 50% of Europeans carry one copy, which gives a 60% reduction. By comparison, less than 40% of people of African descent appear to carry a single copy of the polymorphism."
[http://www.newscientist.com/article/dn12297-genetic-variation-may-lower-hiv-load-by-90.html Genetic variation may lower HIV load by 90%]

They are referring to the (C;C) genotype giving a 90% reduction and the (C;T) giving a 60% reduction.
[http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=9264942 dbSNP page]

This SNP is also reported {{PMID|17641165|OA=1
}} to account for 6.5% of the 15% variation in viral load set point in asymptomatic [[HIV]] infected individuals. [[rs2395029]] can also be associated with reduced HIV viral load set point.

{{ neighbor
| rsid = 10484554
| distance = 175
}}

{{PharmGKB
|RSID=rs9264942
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:17641165
|Annotation=This variant is associated with low HIV viral load (for C allele carriers).
|Drugs=
|Drug Classes=
|Diseases=HIV; HIV Infections
|Curation Level=Curated
|PharmGKB Accession ID=PA162356004
}}

{{PMID Auto GWAS
|PMID=20041166
|Trait=HIV-1 control
|Title=Common Genetic Variation and the Control of HIV-1 in Human
|RiskAllele=
|Pval=6E-12
|OR=NR
|ORtxt=NR
|OA=1
}}

{{PharmGKB
|RSID=rs9264942
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:17641165
|Annotation=In replicated GWAS, rs9264942 explained 6.5% of the total variation in viral set point in HIV-1 infected subjects.
|Drugs=
|Drug Classes=
|Diseases=HIV; HIV Infections
|Curation Level=Curated
|PharmGKB Accession ID=PA162355625
}}

{{PharmGKB
|RSID=rs9264942
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:17641165
|Annotation=This variant is associated with low HIV viral load (for C allele carriers).
|Drugs=
|Drug Classes=
|Diseases=HIV; HIV Infections
|Curation Level=Curated
|PharmGKB Accession ID=PA162316693
}}
{{PMID Auto
|PMID=21067287
|Title=Multiple sclerosis risk markers in HLA-DRA, HLA-C, and IFNG genes are associated with sex-specific childhood leukemia risk
}}

{{PMID Auto GWAS
|PMID=21051598
|Trait=None
|Title=The Major Genetic Determinants of HIV-1 Control Affect HLA Class I Peptide Presentation
|RiskAllele=C
|Pval=3E-35
|OR=2.9000
|ORtxt=[NR]
|OA=1
}}

{{PMID Auto
|PMID=18256235
|Title=WGAViewer: software for genomic annotation of whole genome association studies.
|OA=1
}}

{{PMID Auto
|PMID=18982067
|Title=HIV-1 disease-influencing effects associated with ZNRD1, HCP5 and HLA-C alleles are attributable mainly to either HLA-A10 or HLA-B*57 alleles.
|OA=1
}}

{{PMID Auto
|PMID=19050382
|Title=Association of HLA-C and HCP5 gene regions with the clinical course of HIV-1 infection.
}}

{{PMID Auto
|PMID=19107206
|Title=Distinct genetic loci control plasma HIV-RNA and cellular HIV-DNA levels in HIV-1 infection: the ANRS Genome Wide Association 01 study.
|OA=1
}}

{{PMID Auto
|PMID=19276793
|Title=Host genetics and HIV-1 viral load set-point in African-Americans.
|OA=1
}}

{{PMID Auto
|PMID=20552027
|Title=Host and viral genetic correlates of clinical definitions of HIV-1 disease progression.
|OA=1
}}

{{PMID Auto
|PMID=21221856
|Title=The search for host genetic factors of HIV/AIDS pathogenesis in the post-genome era: progress to date and new avenues for discovery.
|OA=1
}}

{{PMID Auto
|PMID=21499264
|Title=Differential microRNA regulation of HLA-C expression and its association with HIV control.
|OA=1
}}

{{PMID Auto
|PMID=21860345
|Title=Rising HIV-1 viral load set point at a population level coincides with a fading impact of host genetic factors on HIV-1 control.
}}

{{PMID Auto
|PMID=22474614
|Title=Host Genes Important to HIV Replication and Evolution.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs9264942
|overall_frequency_n=38
|overall_frequency_d=124
|overall_frequency=0.306452
|n_genomes=26
|n_genomes_annotated=0
|n_haplomes=33
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=23128233
  |Trait=Crohn's disease
  |Title=Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
  |RiskAllele=C
  |Pval=5E-28
  |OR=1.15
  |ORtxt=[1.107-1.184]
  |OA=1
}}

{{PMID Auto
|PMID=22772778
|Title=Quantity of HLA-C surface expression and licensing of KIR2DL+ natural killer cells.
}}

{{PMID Auto
|PMID=23543094
|Title=Testing for associations between loci and environmental gradients using latent factor mixed models.
|OA=1
}}

{{PMID Auto
|PMID=24842830
|Title=Regulatory variation in HIV-1 dependency factor ZNRD1 associates with host resistance to HIV-1 acquisition
}}

{{PMID Auto
|PMID=25083782
|Title=HLA-C -35kb Expression SNP Is Associated with Differential Control of β-HPV Infection in Squamous Cell Carcinoma Cases and Controls
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}