{{Rsnum
|rsid=9277535
|Gene=HLA-DPB1
|Chromosome=6
|position=33087084
|Orientation=plus
|GMAF=0.3264
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=HLA-DPB1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 55.8 | 36.3 | 8.0
| HCB | 16.1 | 55.5 | 28.5
| JPT | 22.1 | 40.7 | 37.2
| YRI | 78.8 | 21.2 | 0.0
| ASW | 54.4 | 43.9 | 1.8
| CHB | 16.1 | 55.5 | 28.5
| CHD | 14.7 | 47.7 | 37.6
| GIH | 48.5 | 47.5 | 4.0
| LWK | 67.3 | 28.2 | 4.5
| MEX | 58.6 | 37.9 | 3.4
| MKK | 54.8 | 40.6 | 4.5
| TSI | 47.1 | 48.0 | 4.9
| HapMapRevision=28
}}
[http://blog.23andme.com/2009/04/06/snpwatch-immune-system-variations-may-determine-susceptibility-to-chronic-hepatitis-b-infection/ 23andMe blog] [[rs3077]](A) and [[rs9277535]](A) may reduce risk of Hepatitis B infection

{{PMID Auto GWAS
|PMID=19349983
|Trait=Hepatitis B
|Title=A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians
|RiskAllele=G
|Pval=6E-39
}}

{{PharmGKB
|RSID=rs9277535
|Name_s=
|Gene_s=HLA-DPB1
|Feature=
|Evidence=PubMed ID:19349983; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians. (Initial Sample Size: 179 Japanese cases, 934 Japanese controls; Replication Sample Size: 1,599 Japanese cases, 2,821 Japanese controls, 308 Thai cases, 546 Thai controls); (Region: 6p21.32; Reported Gene(s): HLA-DPB1; Risk Allele: rs9277535-G); (p-value= 6E-39).This variant is associated with Hepatitis B.
|Drugs=
|Drug Classes=
|Diseases=Hepatitis B
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164739859
}}

{{PMID Auto
|PMID=21346778
|Title=Risk alleles for chronic hepatitis B are associated with decreased mRNA expression of HLA-DPA1 and HLA-DPB1 in normal human liver
|OA=1
}}

{{PMID Auto
|PMID=21750111
|Title=A Genome-Wide Association Study of Chronic Hepatitis B Identified Novel Risk Locus in a Japanese Population
}}

{{PMID Auto GWAS
|PMID=21764829
|Trait=None
|Title=A genome-wide association study of hepatitis B vaccine response in an Indonesian population reveals multiple independent risk variants in the HLA region.
|RiskAllele=
|Pval=3E-12
|OR=1.3900
|ORtxt=[1.23-1.59]
}}

{{PMID Auto
|PMID=21904616
|Title=Associations of HLA-DP variants with hepatitis B virus infection in southern and northern Han Chinese populations: a multicenter case-control study
|OA=1
}}

{{PMID Auto
|PMID=22543033
|Title=Relationship between HLA-DP gene polymorphisms and clearance of chronic hepatitis B virus infections: Case-control study and meta-analysis
}}

{{PMID Auto
|PMID=22448225
|Title=A common HLA-DPA1 variant is associated with hepatitis B virus infection but fails to distinguish active from inactive Caucasian carriers
|OA=1
}}

{{PMID Auto
|PMID=22807686
|Title=GWAS Identifies Novel Susceptibility Loci on 6p21.32 and 21q21.3 for Hepatocellular Carcinoma in Chronic Hepatitis B Virus Carriers
|OA=1
}}

{{PMID Auto
|PMID=19458352
|Title=Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants.
|OA=1
}}

{{PMID Auto
|PMID=20436909
|Title=The textile plot: a new linkage disequilibrium display of multiple-single nucleotide polymorphism genotype data.
|OA=1
}}

{{PMID Auto
|PMID=20639879
|Title=Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis.
|OA=1
}}

{{PMID Auto
|PMID=21310144
|Title=Non-invasive screening of HLA-DPA1 and HLA-DPB1 alleles for persistent hepatitis B virus infection: susceptibility for vertical transmission and toward a personalized approach for vaccination and treatment.
}}

{{PMID Auto
|PMID=21408128
|Title=Evaluation of genetic susceptibility loci for chronic hepatitis B in Chinese: two independent case-control studies.
|OA=1
}}

{{PMID Auto
|PMID=22105689
|Title=Genetic variants in human leukocyte antigen/DP-DQ influence both hepatitis B virus clearance and hepatocellular carcinoma development.
}}

{{PMID Auto
|PMID=22496224
|Title=A novel variant marking HLA-DP expression levels predicts recovery from hepatitis B virus infection.
|OA=1
}}

{{PMID Auto GWAS
|PMID=22737229
|Trait=None
|Title=Genome-Wide Association Study Confirming Association of HLA-DP with Protection against Chronic Hepatitis B and Viral Clearance in Japanese and Korean.
|RiskAllele=G
|Pval=2E-21
|OR=1.6400
|ORtxt=None
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs9277535
|overall_frequency_n=34
|overall_frequency_d=124
|overall_frequency=0.274194
|n_genomes=18
|n_genomes_annotated=0
|n_haplomes=25
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23326374
|Title=Host genetic factors affecting spontaneous HBsAg seroclearance in chronic hepatitis B patients
|OA=1
}}

{{PMID Auto GWAS
  |PMID=23760081
  |Trait=Chronic hepatitis B infection
  |Title=A genome-wide association study identified new variants associated with the risk of chronic hepatitis B.
  |RiskAllele=
  |Pval=4E-40
  |OR=1.89
  |ORtxt=[1.72-2.08]
  }}

{{PMID Auto
|PMID=23428460
|Title=Genetic variants in HLA-DP/DQ contribute to risk of cervical cancer: a two-stage study in Chinese women.
}}

{{PMID Auto
|PMID=23601003
|Title=Association of the rs3077 and rs9277535 polymorphisms in HLA-DP with hepatitis B virus infection and spontaneous clearance: a meta-analysis.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}