{{Rsnum
|rsid=9282564
|Gene=ABCB1
|Chromosome=7
|position=87600124
|Orientation=plus
|GMAF=0.03811
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=ABCB1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 77.9 | 21.2 | 0.9
| HCB | 100.0 | 0.0 | 0.0
| JPT | 100.0 | 0.0 | 0.0
| YRI | 100.0 | 0.0 | 0.0
| ASW | 94.7 | 5.3 | 0.0
| CHB | 100.0 | 0.0 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 96.0 | 4.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 91.1 | 8.9 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 88.2 | 11.8 | 0.0
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs9282564
|Name_s=ABCB1: c.61A>G, mRNA 479A>G, p.Asn21Asp
|Gene_s=ABCB1
|Feature=Exon/NonSyn
|Evidence=PubMed ID:12065748
|Annotation=Drug efflux and cell surface expression (by MRK-16 and C219 probes) of P-gp was not different between wild-type and variant forms (single mutants: N21D, F103L, S400N, A893S, A998T, and double mutants: 21D-S400N, N21D-A893S, and S400N-A893S) in an in vitro vaccinia virus-based transient expression system. Fluroescent substrates included calcein AM, bodipy-FL-forskolin, bodipy-FL-verapamil, bodipy-FL-vinblastine, bodipy-FL-prazosin, bisantrene, and bodipy-FL-paclitaxel. There was a slight increase in wild-type P-gp efflux of bodipy-FL-paclitaxel over mutants.
|Drugs=bisantrene; calcein; forskolin; prazosin; verapamil; vinblastine
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA165110365
}}

{{PMID Auto
|PMID=18778477
|Title=Genomic variation in myeloma: design, content, and initial application of the Bank On A Cure SNP Panel to detect associations with progression-free survival.
|OA=1
}}

{{GET Evidence
|gene=ABCB1
|aa_change=Asn21Asp
|aa_change_short=N21D
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs9282564
|overall_frequency_n=793
|overall_frequency_d=10758
|overall_frequency=0.0737126
|n_genomes=3
|n_genomes_annotated=0
|n_haplomes=2
|n_articles=1
|n_articles_annotated=1
|in_pharmgkb=Y
|nblosum100=-1
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23133441
|Title=ABCB1 4036A>G and 1236C>T Polymorphisms Affect Plasma Efavirenz Levels in South African HIV/AIDS Patients.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}