{{Rsnum
|rsid=928302
|Gene=TMPRSS3
|Chromosome=21
|position=42389975
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.1175
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=TMPRSS3
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 88.5 | 11.5 | 0.0
| HCB | 67.2 | 32.1 | 0.7
| JPT | 48.2 | 38.4 | 13.4
| YRI | 81.6 | 17.7 | 0.7
| ASW | 84.2 | 10.5 | 5.3
| CHB | 67.2 | 32.1 | 0.7
| CHD | 65.7 | 30.6 | 3.7
| GIH | 91.0 | 9.0 | 0.0
| LWK | 82.7 | 14.5 | 2.7
| MEX | 77.2 | 22.8 | 0.0
| MKK | 89.7 | 10.3 | 0.0
| TSI | 93.1 | 6.9 | 0.0
| HapMapRevision=28
}}{{Venter SNP
|rsid=928302
|allele=T
|frequency=0.067
|uid=1103643127594
|type=heterozygous_SNP
|hugo=TMPRSS3
|ensembl gene=ENSG00000160183
|ensembl transcript=ENST00000291532
|sift=TOLERATED
|disease=Defects in TMPRSS3 are a cause of congenital autosomal recessive neurosensory deafness 10 (DFNB10) (MIM:605316).
}}

{{PharmGKB
|RSID=rs928302
|Name_s=
|Gene_s=TMPRSS3
|Feature=
|Evidence=PubMed ID:19268276
|Annotation=In a GWAS of 3497 Dutch subjects from the Netherlands Study of Depression and Anxiety or from the Netherlands Twin Registry, this SNP was found to be associated with Smoking Initiation (p = 0.0000123; OR for minor allele T:0.659)
|Drugs=nicotine
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA164920618
}}

{{ClinVar
|rsid=928302
|Reversed=0
|FwdREF=C
|FwdALT=T
|REF=C
|ALT=T
|RSPOS=43810084
|CHROM=21
|GMAF=0.1172
|dbSNPBuildID=86
|SSR=0
|SAO=1
|VP=0x05016800000015051f100100
|GENEINFO=TMPRSS3:64699
|GENE_NAME=TMPRSS3
|GENE_ID=64699
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000021.8:g.43810084C>T
|CLNORIGIN=1
|CLNSIG=2
|Tags=PM;PMC;SLO;VLD;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD
|CAF=0.8825; 0.1175
|CLNACC=RCV000039342.1
|CLNDBN=AllHighlyPenetrant
|CLNDSDB=MedGen
|CLNDSDBID=CN169374
|COMMON=1
|Disease=AllHighlyPenetrant
}}

{{PMID Auto
|PMID=18817904
|Title=Japanese population structure, based on SNP genotypes from 7003 individuals compared to other ethnic groups: effects on population-based association studies.
|OA=1
}}

{{PMID Auto
|PMID=11137999
|Title=Insertion of beta-satellite repeats identifies a transmembrane protease causing both congenital and childhood onset autosomal recessive deafness.
}}

{{GET Evidence
|gene=TMPRSS3
|aa_change=Val53Ile
|aa_change_short=V53I
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs928302
|overall_frequency_n=875
|overall_frequency_d=10758
|overall_frequency=0.0813348
|n_genomes=13
|n_genomes_annotated=0
|n_haplomes=14
|n_articles=1
|n_articles_annotated=1
|gene_in_genetests=Y
|in_pharmgkb=Y
|pph2_score=0.36
|genetests_testable=Y
|nblosum100=-4
|autoscore=3
|webscore=N
|n_web_uneval=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}