{{Rsnum
|rsid=9288516
|Gene=XRCC5
|Chromosome=2
|position=216188541
|Orientation=plus
|GMAF=0.1809
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;T)
|geno3=(T;T)
|Gene_s=XRCC5
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;T)
| geno3=(T;T)
| CEU | 0.0 | 0.0 | 100.0
| HCB | 22.2 | 53.3 | 24.4
| JPT | 29.5 | 47.7 | 22.7
| YRI | 0.0 | 0.0 | 100.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 22.2 | 53.3 | 24.4
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[[rs9288516]] is a SNP in the [[XRCC5]] gene.

A study of ~700 Chinese patients with [[hepatocellular carcinoma]] (HCC) compared to controls indicated an increased risk for [[rs9288516]](A) carriers (odds ratio 2.02, CI: 1.42-2.86, TA+AA versus TT) even after Bonferroni correction (P(corrected) = 0.002). The effect was more significant in HBsAg infected subjects than non-infected subjects.{{PMID|21304054}}{{PMID Auto
|PMID=17389609
|Title=Tagging SNPs in non-homologous end-joining pathway genes and risk of glioma.
}}

{{PMID Auto
|PMID=19318434
|Title=Associations between polymorphisms in DNA repair genes and glioblastoma.
|OA=1
}}