{{Rsnum
|rsid=9296249
|Gene=BTBD9
|Chromosome=6
|position=38398065
|Orientation=plus
|GMAF=0.3815
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=BTBD9
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 3.5 | 38.9 | 57.5
| HCB | 29.2 | 50.4 | 20.4
| JPT | 28.3 | 50.4 | 21.2
| YRI | 20.4 | 47.6 | 32.0
| ASW | 28.1 | 50.9 | 21.1
| CHB | 29.2 | 50.4 | 20.4
| CHD | 22.0 | 41.3 | 36.7
| GIH | 14.9 | 44.6 | 40.6
| LWK | 10.9 | 50.9 | 38.2
| MEX | 20.7 | 48.3 | 31.0
| MKK | 6.4 | 40.4 | 53.2
| TSI | 4.9 | 43.1 | 52.0
| HapMapRevision=28
}}[[rs9296249]], a SNP located in the [[BTBD9]] gene region, has been linked to a lower frequency of [[restless legs syndrome]], a common sleep disorder, with an overall odds ratio of 0.62 (CI: 0.52-0.75) for the (C) minor allele. {{PMID|17637780}}
{{ neighbor
| rsid = 9357271
| distance = 32
}}

{{GWAS Summary
|SNP=rs9296249
|PubMedID=17637780
|Condition=Restless legs syndrome
|Gene=BTBD9
|Risk Allele=T
|pValue=4.00E-018
|OR=1.67
|95CI=1.49-1.89
}}

{{omim
|desc=RESTLESS LEGS SYNDROME, SUSCEPTIBILITY TO, 6
|id=611185
|rsnum=9296249
}}
{{PMID Auto
|PMID=19223043
|Title=Exploring the genetic link between RLS and [[ADHD]]
}}

{{PharmGKB
|RSID=rs9296249
|Name_s=
|Gene_s=BTBD9
|Feature=
|Evidence=PubMed ID:17637780; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions (Initial Sample Size: 401 cases, 1,644 controls; Replication Sample Size: 1,158 cases, 1,178 controls; Risk Allele: rs9296249-T).
|Drugs=
|Drug Classes=
|Diseases=Restless Legs Syndrome
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356678
}}

{{PharmGKB
|RSID=rs9296249
|Name_s=
|Gene_s=BTBD9
|Feature=
|Evidence=PubMed ID:17637780
|Annotation=In replicated GWAS case-control studies of Caucasian(European and French-Canadian) familial and sporadic RLS, the T allele of rs9296249 was significantly associated with Restless Legs Syndrome.
|Drugs=
|Drug Classes=
|Diseases=Restless Legs Syndrome
|Curation Level=Curated
|PharmGKB Accession ID=PA162355627
}}

{{PMID Auto
|PMID=19279021
|Title=Replication of restless legs syndrome loci in three European populations.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs9296249
|overall_frequency_n=40
|overall_frequency_d=128
|overall_frequency=0.3125
|n_genomes=33
|n_genomes_annotated=0
|n_haplomes=41
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=22914617
|Title=Analysis of the BTBD9 and HTR2C variants in Chinese Han patients with Tourette syndrome.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}