{{Rsnum
|rsid=9298506
|Gene=SEC11B
|Chromosome=8
|position=54524964
|Orientation=plus
|GMAF=0.1878
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 61.6 | 35.7 | 2.7
| HCB | 62.8 | 32.1 | 5.1
| JPT | 61.1 | 31.9 | 7.1
| YRI | 68.7 | 28.6 | 2.7
| ASW | 73.7 | 24.6 | 1.8
| CHB | 62.8 | 32.1 | 5.1
| CHD | 66.1 | 30.3 | 3.7
| GIH | 59.4 | 36.6 | 4.0
| LWK | 50.9 | 43.6 | 5.5
| MEX | 75.9 | 22.4 | 1.7
| MKK | 52.9 | 43.9 | 3.2
| TSI | 80.4 | 17.6 | 2.0
| HapMapRevision=28
}}Based on a large study (~6,000 cases and 14,000 controls) of both European and Japanese populations, the [[rs9298506]](A) allele has been associated with higher risk of [[aneurysm]], with an odds ratio per allele of 1.28 (CI:1.20-1.38, p=1.0e-06). {{PMID|20364137|OA=1
}}

{{PMID Auto GWAS
|PMID=18997786
|Trait=Intracranial aneurysm
|Title=Susceptibility loci for intracranial aneurysm in European and Japanese populations
|RiskAllele=A
|Pval=2E-9
|OR=1.35
|ORtxt=[1.22-1.49]
|OA=1
}}

{{PharmGKB
|RSID=rs9298506
|Name_s=
|Gene_s=SEC11L2
|Feature=
|Evidence=PubMed ID:18997786; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Susceptibility loci for intracranial aneurysm in European and Japanese populations. (Initial Sample Size: 1,580 European cases, 6,276 European controls; Replication Sample Size: 495 Japanese cases, 676 Japanese controls); (Region: 8q11.23-q12.1; Reported Gene(s): SOX17; Risk Allele: rs9298506-A); (p-value= 0.000000002).This variant is associated with Intracranial aneurysm.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740746
}}

{{omim
|id=612587
|rsnum=9298506
}}

{{PMID Auto
|PMID=17903302
|Title=Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs9298506
|overall_frequency_n=27
|overall_frequency_d=128
|overall_frequency=0.210938
|n_genomes=18
|n_genomes_annotated=0
|n_haplomes=19
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

[[Brain Aneurysm]]

{{PMID Auto
|PMID=23733552
|Title=Genetic risk factors for intracranial aneurysms: a meta-analysis in more than 116,000 individuals.
|OA=1
}}

{{PMID Auto
|PMID=25053769
|Title=Evaluation of genetic risk loci for intracranial aneurysms in sporadic arteriovenous malformations of the brain
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}