{{Rsnum
|rsid=9300039
|Chromosome=11
|position=41893816
|Orientation=plus
|GMAF=0.1345
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 0.0 | 26.1 | 73.9
| HCB | 6.7 | 46.7 | 46.7
| JPT | 2.2 | 51.1 | 46.7
| YRI | 0.7 | 28.7 | 70.6
| ASW | 0.0 | 15.8 | 84.2
| CHB | 6.7 | 46.7 | 46.7
| CHD | 10.3 | 42.1 | 47.7
| GIH | 1.0 | 33.3 | 65.7
| LWK | 0.9 | 31.1 | 67.9
| MEX | 1.8 | 7.3 | 90.9
| MKK | 0.0 | 14.6 | 85.4
| TSI | 0.0 | 12.1 | 87.9
| HapMapRevision=28
}}
[[rs9300039]], a SNP on chromosome 11 that is unusual is being over 1,000,000 base-pairs away from the nearest known gene, has been identified as a risk factor for [[type-2 diabetes]] in a study of over 2,000 Caucasian patients. The odds ratio for the risk allele [[rs9300039]](C) was 1.48, (CI: 1.28-1.71, p=5.7x10e-8). {{PMID|17463248|OA=1
}}

This SNP is also mentioned in a related [http://suicyte.wordpress.com/2007/05/28/soul-searching-ii/ blog] series.

Called into question by table 1 of {{doi|10.1371/journal.pbio.1000294}}

{{GWAS Summary
|SNP=rs9300039
|PubMedID=17463248
|Condition=Type 2 diabetes
|Gene=Intergenic
|Risk Allele=C
|pValue=4.00E-007
|OR=1.25
|95CI=1.15-1.37
|OA=1
}}

{{PharmGKB
|RSID=rs9300039
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:17463248; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants (Initial Sample Size: 1,161 cases, 1,174 controls; Replication Sample Size: 1,215 cases, 1,258 controls; Risk Allele: rs9300039-C).
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus; Diabetes Mellitus, Type 2
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356613
}}

{{PharmGKB
|RSID=rs9300039
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:17463248
|Annotation=In a large Finnish case-control GWAS, rs9300039 was found to be associated with susceptibility to Type 2 Diabetes.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus, Type 2
|Curation Level=Curated
|PharmGKB Accession ID=PA162191357
}}

{{PMID|17786212|OA=1
}} Heterogeneity in meta-analyses of genome-wide association investigations.

{{PMID|17827400}} Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies.

{{PMID|18162508}} Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population.

{{PMID|18224312|OA=1
}} Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.

{{PMID|18443202|OA=1
}} Association analysis in african americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies.

{{PMID|18633108|OA=1
}} Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population.

{{PMID|18689899|OA=1
}} Exchangeable models of complex inherited diseases.

{{PMID|19008344|OA=1
}} Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians.

{{PMID|20554072}} Gestational diabetes mellitus screening based on the gene chip technique.

{{PMID|20823317|OA=1
}} is-rSNP: a novel technique for in silico regulatory SNP detection.

{{PMID|21278902|OA=1
}} Genetic risk profiling for prediction of type 2 diabetes.

{{PMID|21283728|OA=1
}} Genetic variants of diabetes risk and incident cardiovascular events in chronic coronary artery disease.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs9300039
|overall_frequency_n=10
|overall_frequency_d=128
|overall_frequency=0.078125
|n_genomes=9
|n_genomes_annotated=0
|n_haplomes=9
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}