{{Rsnum
|rsid=9302752
|Chromosome=16
|position=50685192
|Orientation=plus
|GMAF=0.438
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 55.8 | 37.2 | 7.1
| HCB | 8.8 | 40.9 | 50.4
| JPT | 4.4 | 42.5 | 53.1
| YRI | 36.7 | 47.6 | 15.6
| ASW | 49.1 | 38.6 | 12.3
| CHB | 8.8 | 40.9 | 50.4
| CHD | 12.8 | 33.0 | 54.1
| GIH | 12.9 | 35.6 | 51.5
| LWK | 38.2 | 50.9 | 10.9
| MEX | 24.1 | 41.4 | 34.5
| MKK | 64.1 | 32.7 | 3.2
| TSI | 55.9 | 39.2 | 4.9
| HapMapRevision=28
}}Variant in the [[NOD2]] gene associated with greater susceptibility to [[leprosy]] in Asians, according to the [http://blog.23andme.com/2009/12/16/snpwatch-genetic-association-study-of-leprosy-yields-new-insights-into-an-ancient-disease/ 23andMe blog]. The risk allele is C, and the odds ratio is 1.59. 

Another gene associated with susceptibility to [[leprosy]] is [[TNFSF15]]. SNPs in both the [[NOD2]] and [[TNFSF15]] genes are also associated with susceptibility to [[Crohn's disease]].
{{PMID Auto GWAS
|PMID=20018961
|Trait=Leprosy
|Title=Genomewide Association Study of Leprosy
|RiskAllele=G
|Pval=4E-40
|OR=1.59
|ORtxt=[1.49-1.71]
}}

{{PMID Auto
|PMID=22212192
|Title=Polymorphisms of NOD2 and the risk of tuberculosis: a validation study in the Chinese population
}}

{{PMID Auto
|PMID=22504414
|Title=Association between C13ORF31, NOD2, RIPK2 and TLR10 polymorphisms and urothelial bladder cancer.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs9302752
|overall_frequency_n=83
|overall_frequency_d=128
|overall_frequency=0.648438
|n_genomes=48
|n_genomes_annotated=0
|n_haplomes=69
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=2
|webscore=N
}}

[[Leprosy Susceptibility]]

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}