{{Rsnum
|rsid=9332377
|Gene=COMT
|Chromosome=22
|position=19968169
|Orientation=plus
|GMAF=0.1584
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=ARVCF,COMT
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 69.0 | 27.4 | 3.5
| HCB | 99.3 | 0.7 | 0.0
| JPT | 100.0 | 0.0 | 0.0
| YRI | 38.8 | 51.7 | 9.5
| ASW | 40.4 | 42.1 | 17.5
| CHB | 99.3 | 0.7 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 66.3 | 28.7 | 5.0
| LWK | 44.5 | 40.9 | 14.5
| MEX | 82.8 | 17.2 | 0.0
| MKK | 36.8 | 51.0 | 12.3
| TSI | 69.3 | 27.7 | 3.0
| HapMapRevision=28
}}[http://blog.23andme.com/2009/11/10/snpwatch-genetic-variations-may-impact-risk-of-hearing-loss-in-children-receiving-common-chemotherapy-drug/ 23andMe blog] hearing loss linked to a chemotherapy drug named [[Cisplatin]].

{{PMID Auto
|PMID=20979063
|Title=Why do young women smoke? VII COMT as a risk modifying gene for Nicotine dependence - role of gene-gene interaction, personality, and environmental factors
}}

{{PharmGKB
|RSID=rs9332377
|Name_s=COMT:rs9332377 A/G
|Gene_s=COMT, ARVCF
|Feature=
|Evidence=PubMed ID:19898482
|Annotation=Risk or phenotype-associated allele: A. Phenotype: This variant was associated with cisplatin-induced hearing loss from a large candidate gene screen in 2 pediatric cohorts.. Study size: 54 (discovery); 112 (replication). Study population/ethnicity: Children with neoplasms receiving cisplatin; Canada. Significance metric(s): OR = 5.52 (CI 1.91, 15.95); p = 0.000182 Type of association: CO; TOX; ADR
|Drugs=cisplatin
|Drug Classes=
|Diseases=Drug Toxicity; Ototoxicity
|Curation Level=Curated
|PharmGKB Accession ID=PA165291586
}}

{{omim
|id=613290
|rsnum=9332377
}}

{{PMID Auto
|PMID=18436194
|Title=Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes.
|OA=1
}}

{{PMID Auto
|PMID=18937309
|Title=Sexually dimorphic effects of four genes (COMT, SLC6A2, MAOA, SLC6A4) in genetic associations of ADHD: a preliminary study.
|OA=1
}}

{{PMID Auto
|PMID=19015200
|Title=Polymorphisms in estrogen- and androgen-metabolizing genes and the risk of gastric cancer.
|OA=1
}}

{{PMID Auto
|PMID=20667552
|Title=Catechol-o-methyltransferase gene modulation on suicidal behavior and personality traits: review, meta-analysis and association study.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs9332377
|overall_frequency_n=23
|overall_frequency_d=128
|overall_frequency=0.179688
|n_genomes=16
|n_genomes_annotated=0
|n_haplomes=20
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}