{{Rsnum
|rsid=9332964
|Gene=SRD5A2
|Chromosome=2
|position=31529325
|Orientation=minus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.0009183
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=SRD5A2
}}[[rs9332964]] is a nonsynonymous change known as R227Q in the [[SRD5A2]] gene. The [[SRD5A2]] gene encodes steroid 5-alpha-reductase, an enzyme which catalyzes the conversion of testosterone in the body. Polymorphisms in [[SRD5A2]] have been implicated in several disorders of male sexual development such as [http://en.wikipedia.org/wiki/Micropenis micropenis]. The homozygous [[rs9332964(A;A)]] genotype has been observed in several Japenese males with [[micropenis]]. {{PMID|12843198}}

{{omim
|desc=MICROPENIS
|id=607306
|rsnum=9332964
|variant=0016
}}

{{ClinVar
|rsid=9332964
|Reversed=1
|FwdREF=G
|FwdALT=A
|REF=C
|ALT=T
|RSPOS=31754395
|CHROM=2
|GMAF=0.0009
|dbSNPBuildID=119
|SSR=0
|SAO=1
|VP=0x050168000000040116110100
|GENEINFO=SRD5A2:6716
|GENE_NAME=SRD5A2
|GENE_ID=6716
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000002.11:g.31754395C>T
|CLNORIGIN=1
|CLNSIG=5
|Tags=RV;PM;PMC;SLO;VLD;GNO;KGPhase1;KGPROD;OTHERKG;LSD;OM
|CAF=0.9991; 0.0009183
|CLNACC=RCV000003515.1; RCV000083663.1
|CLNDBN=Micropenis; not provided
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=607306.0016
|COMMON=1
|Disease=Micropenis; not provided
}}

{{PMID Auto
|PMID=18163429
|Title=Genetic polymorphisms in CYP17, CYP3A4, CYP19A1, SRD5A2, IGF-1, and IGFBP-3 and prostate cancer risk in African-American men: the Flint Men's Health Study.
|OA=1
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}