{{Rsnum
|rsid=9357271
|Gene=BTBD9
|Chromosome=6
|position=38398097
|Orientation=plus
|GMAF=0.4734
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=BTBD9
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 4.4 | 38.1 | 57.5
| HCB | 76.3 | 22.9 | 0.8
| JPT | 68.5 | 27.9 | 3.6
| YRI | 36.6 | 51.4 | 12.0
| ASW | 45.6 | 47.4 | 7.0
| CHB | 76.3 | 22.9 | 0.8
| CHD | 68.3 | 28.8 | 2.9
| GIH | 36.6 | 49.5 | 13.9
| LWK | 33.9 | 48.6 | 17.4
| MEX | 29.3 | 51.7 | 19.0
| MKK | 16.7 | 50.6 | 32.7
| TSI | 4.9 | 44.1 | 51.0
| HapMapRevision=28
}}[[rs9357271]], a SNP located in the [[BTBD9]] gene region, has been linked to a lower frequency of [[restless legs syndrome]], a common sleep disorder, with an overall odds ratio of 0.63 (CI: 0.52-0.75) for the (C) minor allele. {{PMID|17637780}}

This SNP may also be associated with [[Tourette syndrome]] (TS), particularly TS without obsessive-compulsive disorder, based on a study of ~600 patients.{{PMID|19822783}} 

{{ neighbor
| rsid = 9296249
| distance = 32
}}

{{omim
|desc=RESTLESS LEGS SYNDROME, SUSCEPTIBILITY TO, 6
|id=611185
|rsnum=9357271
}}

{{PharmGKB
|RSID=rs9357271
|Name_s=
|Gene_s=BTBD9
|Feature=
|Evidence=PubMed ID:17637780
|Annotation=In replicated GWAS case-control studies of Caucasian(European and French-Canadian) familial and sporadic RLS, the T allele of rs9357271 was significantly associated with Restless Legs Syndrome.
|Drugs=
|Drug Classes=
|Diseases=Restless Legs Syndrome
|Curation Level=Curated
|PharmGKB Accession ID=PA162355628
}}

{{PMID Auto GWAS
|PMID=21779176
|Trait=None
|Title=Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1.
|RiskAllele=T
|Pval=8E-22
|OR=1.4700
|ORtxt=[1.35-1.47]
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs9357271
|overall_frequency_n=60
|overall_frequency_d=128
|overall_frequency=0.46875
|n_genomes=40
|n_genomes_annotated=0
|n_haplomes=57
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23361623
|Title=The BTBD9 gene may be associated with antipsychotic-induced restless legs syndrome in schizophrenia
}}

{{PMID Auto
|PMID=22914617
|Title=Analysis of the BTBD9 and HTR2C variants in Chinese Han patients with Tourette syndrome.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}