{{Rsnum
|rsid=942519
|Gene=DFNB31
|Chromosome=9
|position=114406753
|Orientation=plus
|ReferenceAllele=T
|MissenseAllele=C
|GMAF=0.4876
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=DFNB31
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 17.7 | 53.1 | 29.2
| HCB | 28.7 | 44.9 | 26.5
| JPT | 12.4 | 46.0 | 41.6
| YRI | 39.5 | 50.3 | 10.2
| ASW | 31.6 | 57.9 | 10.5
| CHB | 28.7 | 44.9 | 26.5
| CHD | 27.8 | 45.4 | 26.9
| GIH | 15.8 | 43.6 | 40.6
| LWK | 40.0 | 47.3 | 12.7
| MEX | 25.9 | 48.3 | 25.9
| MKK | 34.0 | 47.4 | 18.6
| TSI | 22.8 | 54.5 | 22.8
| HapMapRevision=28
}}{{Venter SNP
|rsid=942519
|allele=G
|frequency=0.43
|uid=1103652166722
|type=heterozygous_SNP
|hugo=DFNB31
|ensembl gene=ENSG00000095397
|ensembl transcript=ENST00000362057
|sift=TOLERATED
|disease=Defects in WHRN are a cause of autosomal recessive deafness type 31 (DFNB31) (MIM:607084). This sensorineural hearing loss is bilateral and profound and manifests itself already in the prelingual period in early childhood.
}}

{{ClinVar
|rsid=942519
|Reversed=0
|FwdREF=A
|FwdALT=G
|REF=A
|ALT=G
|RSPOS=117169033
|CHROM=9
|GMAF=0.4863
|dbSNPBuildID=86
|SSR=0
|SAO=1
|VP=0x05016800000017051f100100
|GENEINFO=DFNB31:25861
|GENE_NAME=DFNB31
|GENE_ID=25861
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000009.11:g.117169033A>G
|CLNORIGIN=1
|CLNSIG=2
|Tags=PM;PMC;SLO;VLD;G5A;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD
|CAF=0.5124; 0.4876
|CLNACC=RCV000038881.2
|CLNDBN=AllHighlyPenetrant
|CLNDSDB=MedGen
|CLNDSDBID=CN169374
|COMMON=1
|Disease=AllHighlyPenetrant
|CLNSRC=Emory University
|CLNSRCID=13645
}}

{{PMID|20352026|OA=1
}} Sequence variants of the DFNB31 gene among Usher syndrome patients of diverse origin.

{{PMID|20583170|OA=1
}} Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate.

{{PMID|15841483}} Identification of a novel frameshift mutation in the DFNB31/WHRN gene in a Tunisian consanguineous family with hereditary non-syndromic recessive hearing loss.

{{GET Evidence
|gene=DFNB31
|aa_change=Met613Thr
|aa_change_short=M613T
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs942519
|overall_frequency_n=5295
|overall_frequency_d=10756
|overall_frequency=0.492283
|n_genomes=45
|n_genomes_annotated=0
|n_haplomes=58
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|genetests_testable=Y
|genetests_reviewed=Y
|nblosum100=2
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}