{{Rsnum
|rsid=944289
|Chromosome=14
|position=36180040
|Orientation=plus
|GMAF=0.4288
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 18.6 | 42.5 | 38.9
| HCB | 29.4 | 51.5 | 19.1
| JPT | 36.3 | 48.7 | 15.0
| YRI | 78.9 | 19.0 | 2.0
| ASW | 64.9 | 33.3 | 1.8
| CHB | 29.4 | 51.5 | 19.1
| CHD | 28.4 | 55.0 | 16.5
| GIH | 23.8 | 54.5 | 21.8
| LWK | 76.1 | 20.2 | 3.7
| MEX | 41.4 | 39.7 | 19.0
| MKK | 66.0 | 30.1 | 3.8
| TSI | 24.5 | 35.3 | 40.2
| HapMapRevision=28
}}{{PMID|19198613|OA=1
}} Each A at [[rs965513]] increased the odds of [[thyroid cancer]] by 1.75 times. Each T at [[rs944289]] increased the odds of thyroid cancer by 1.37 times.

A [[genoset]], [[Gs137]], has also been created in SNPedia to represent the increased risk reported for carriers of both variants.

See also: [http://blog.23andme.com/2009/02/06/snpwatch-two-gene-variations-linked-to-thyroid-cancer/ 23andMe blog]

{{omim
|desc=THYROID CARCINOMA, FOLLICULAR; FTC
|id=188470
|rsnum=944289
}}

{{omim
|desc=THYROID CARCINOMA, PAPILLARY
|id=188550
|rsnum=944289
}}

{{PharmGKB
|RSID=rs944289
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19198613; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Common variants on 9q22.33 and 14q13.3 predispose to thyroid cancer in European populations. (Initial Sample Size: 192 cases, 37,196 controls; Replication Sample Size: 432 cases, 1,727 controls); (Region: 14q13.3; Reported Gene(s): NKX2-1; Risk Allele: rs944289-T); (p-value= 0.000000002).This variant is associated with Thyroid cancer.
|Drugs=
|Drug Classes=
|Diseases=Thyroid Neoplasms
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164739982
}}

{{PMID Auto
|PMID=20350937
|Title=The FOXE1 locus is a major genetic determinant for radiation-related thyroid carcinoma in Chernobyl
}}

{{PMID Auto
|PMID=21730105
|Title=The FOXE1 and NKX2-1 loci are associated with susceptibility to papillary thyroid carcinoma in the Japanese population
}}

{{PMID Auto
|PMID=22282540
|Title=Thyroid cancer susceptibility polymorphisms: confirmation of loci on chromosomes 9q22 and 14q13, validation of a recessive 8q24 locus and failure to replicate a locus on 5q24
|OA=1
}}

{{PMID Auto
|PMID=22586128
|Title=The polymorphism rs944289 predisposes to papillary thyroid carcinoma through a large intergenic noncoding RNA gene of tumor suppressor type
|OA=1
}}

{{PMID Auto
|PMID=20628519
|Title=Genetic Predisposition to Familial Nonmedullary Thyroid Cancer: An Update of Molecular Findings and State-of-the-Art Studies.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs944289
|overall_frequency_n=51
|overall_frequency_d=128
|overall_frequency=0.398438
|n_genomes=30
|n_genomes_annotated=0
|n_haplomes=40
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23659773
|Title=Cumulative Risk Impact of Five Genetic Variants Associated With Papillary Thyroid Carcinoma
}}

{{PMID Auto
|PMID=23847140
|Title=Confirmation of papillary thyroid cancer susceptibility loci identified by genome-wide association studies of chromosomes 14q13, 9q22, 2q35 and 8p12 in a Chinese population
}}

{{PMID Auto
|PMID=24325646
|Title=FOXE1 association with differentiated thyroid cancer and its progression
}}

{{PMID Auto
|PMID=24591304
|Title=Significant SNPs have limited prediction ability for thyroid cancer
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}