{{Rsnum
|rsid=9465871
|Gene=CDKAL1
|Chromosome=6
|position=20717024
|Orientation=plus
|GMAF=0.3627
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=CDKAL1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 3.5 | 25.7 | 70.8
| HCB | 26.3 | 50.4 | 23.4
| JPT | 22.1 | 46.9 | 31.0
| YRI | 36.1 | 42.9 | 21.1
| ASW | 22.8 | 59.6 | 17.5
| CHB | 26.3 | 50.4 | 23.4
| CHD | 30.3 | 42.2 | 27.5
| GIH | 2.0 | 38.6 | 59.4
| LWK | 36.4 | 50.9 | 12.7
| MEX | 8.6 | 46.6 | 44.8
| MKK | 26.3 | 46.8 | 26.9
| TSI | 3.9 | 23.5 | 72.5
| HapMapRevision=28
}}[[rs9465871]] has been reported in a large study to be associated with [[type-2 diabetes]].

The risk allele (oriented to the dbSNP entry) is (C); the odds ratio associated with heterozygotes is 1.18 (CI 1.04-1.34), and for homozygotes, 2.17 (CI 1.6-2.95). {{PMID|17554300|OA=1
}}

{{PMID|18633108|OA=1
}} When combined, each additional risk allele from [[rs9465871]], [[rs10811661]], [[rs4402960]], and [[rs13266634]] increased the risk for type 2 diabetes by 1.24-fold (P = 2.85 x 10(-7)) or for combined IFG/type 2 diabetes by 1.21-fold (P = 6.31 x 10(-11)) in Chinese Hans

{{GWAS Summary
|SNP=rs9465871
|PubMedID=17554300
|Condition=Type 2 diabetes
|Gene=CDKAL1
|Risk Allele=C
|pValue=3.00E-007
|OR=1.18
|95CI=1.04-1.34
|OA=1
}}

{{omim
|desc=DIABETES MELLITUS, NONINSULIN-DEPENDENT; NIDDM
|id=125853
|rsnum=9465871
}}

{{PharmGKB
|RSID=rs9465871
|Name_s=
|Gene_s=CDKAL1
|Feature=
|Evidence=PubMed ID:17554300; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls (Initial Sample Size: 1,924 cases, 2,938 controls; Replication Sample Size: (see Zeggini 2007); Risk Allele: rs9465871-C). This variant is associated with type 2 diabetes.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus; Diabetes Mellitus, Type 2
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356659
}}

{{PMID|18224312|OA=1
}} Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.

{{PMID|19862325|OA=1
}} PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population.

{{PMID|19931040|OA=1
}} Simultaneous genotype calling and haplotype phasing improves genotype accuracy and reduces false-positive associations for genome-wide association studies.

{{PMID|20847106}} Association of a cyclin-dependent kinase 5 regulatory subunit-associated protein 1-like 1 (CDKAL1) polymorphism with elevated hemoglobin A(1)(c) levels and the prevalence of metabolic syndrome in Japanese men: interaction with dietary energy intake.

{{PMID|21368910|OA=1
}} Heterogeneity of genetic associations of CDKAL1 and HHEX with susceptibility of type 2 diabetes mellitus by gender.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs9465871
|overall_frequency_n=55
|overall_frequency_d=128
|overall_frequency=0.429688
|n_genomes=34
|n_genomes_annotated=0
|n_haplomes=48
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}