{{Rsnum
|rsid=9469220
|Chromosome=6
|position=32690533
|Orientation=plus
|GMAF=0.4192
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 20.4 | 47.8 | 31.9
| HCB | 43.7 | 44.4 | 11.9
| JPT | 44.6 | 46.4 | 8.9
| YRI | 28.6 | 49.7 | 21.8
| ASW | 36.8 | 43.9 | 19.3
| CHB | 43.7 | 44.4 | 11.9
| CHD | 47.7 | 41.3 | 11.0
| GIH | 41.6 | 41.6 | 16.8
| LWK | 35.5 | 49.1 | 15.5
| MEX | 31.0 | 56.9 | 12.1
| MKK | 21.3 | 54.2 | 24.5
| TSI | 40.6 | 43.6 | 15.8
| HapMapRevision=28
}}[[rs9469220]] has been reported in a large study to be associated with [[Crohn's disease]].

The risk allele (oriented to the dbSNP entry) is (A); the odds ratio associated with heterozygotes is 1.14 (CI 0.98-1.32), and for homozygotes, 1.52 (CI 1.28-1.79). {{PMID|17554300|OA=1
}}

{{GWAS Summary
|SNP=rs9469220
|PubMedID=17554300
|Condition=Crohn's disease
|Gene=NR
|Risk Allele=A
|pValue=2.00E-006
|OR=1.14
|95CI=0.98-1.32
|OA=1
}}

{{PharmGKB
|RSID=rs9469220
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:17554300; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls (Initial Sample Size: 1,748 cases, 2,938 controls; Replication Sample Size: (see Parkes 2007); Risk Allele: rs9469220-A). This variant is associated with crohn's disease.
|Drugs=
|Drug Classes=
|Diseases=Crohn Disease
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356660
}}

{{PMID Auto
|PMID=22615847
|Title=Association Analysis of the Extended MHC Region in Celiac Disease Implicates Multiple Independent Susceptibility Loci
|OA=1
}}

{{PMID Auto
|PMID=17660530
|Title=Risk alleles for multiple sclerosis identified by a genomewide study.
}}

{{PMID Auto
|PMID=20369022
|Title=Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations.
|OA=1
}}

{{PMID Auto
|PMID=20546594
|Title=An application of Random Forests to a genome-wide association dataset: methodological considerations & new findings.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs9469220
|overall_frequency_n=71
|overall_frequency_d=122
|overall_frequency=0.581967
|n_genomes=43
|n_genomes_annotated=0
|n_haplomes=62
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=23146381
  |Trait=IgE levels
  |Title=A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations.
  |RiskAllele=G
  |Pval=2E-7
  |OR=.09
  |ORtxt=[0.05-0.12] unit decrease
  |OA=1
}}

{{PMID Auto
|PMID=24352087
|Title=Candidate genes involved in beneficial or adverse responses to commonly eaten brassica vegetables in a New Zealand Crohn's disease cohort
}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}