{{Rsnum
|rsid=951266
|Gene=CHRNA5
|Chromosome=15
|position=78586199
|Orientation=plus
|GMAF=0.1892
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=CHRNA5
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 38.4 | 45.5 | 16.1
| HCB | 94.9 | 5.1 | 0.0
| JPT | 95.6 | 4.4 | 0.0
| YRI | 83.0 | 16.3 | 0.7
| ASW | 73.7 | 26.3 | 0.0
| CHB | 94.9 | 5.1 | 0.0
| CHD | 90.8 | 9.2 | 0.0
| GIH | 63.4 | 31.7 | 5.0
| LWK | 90.9 | 9.1 | 0.0
| MEX | 62.1 | 32.8 | 5.2
| MKK | 76.3 | 23.1 | 0.6
| TSI | 36.6 | 45.5 | 17.8
| HapMapRevision=28
}}

{{Report GE
|PubMed=18385738
|Source=journal
|AffyProbeset=SNP_A-4302972
|AffyOrientation=same
|AlleleA=C
|AlleleB=T
|onGW5=
|rsid=951266
|ancestral=C
|RiskPopulation=Caucasian(Europe)
|RiskAllele=T
|CaseFreq=0.4
|ControlFreq=0.34
|OddsRatioHet=
|OddsRatioHom=
|OddsRatioAll=1.30
|Disease=Lung cancer
|DiseaseSymbol=LC
}}

rs951266 increases susceptibility to Lung cancer 1.28 times for heterozygotes (CT) and 1.80 times for homozygotes (TT) {{PMID|18385676|OA=1
}}

rs951266 increases susceptibility to Lung cancer 1.30 times for carriers of the T allele {{PMID|18385738}}

rs951266 increases susceptibility to Lung cancer 1.32 times for heterozygotes (CT) and 1.70 times for homozygotes (TT) {{PMID|18385739}}

rs951266 increases susceptibility to Peripheral arterial disease 1.21 times for heterozygotes (CT) and 1.41 times for homozygotes (TT) {{PMID|18385739}}

rs951266 increases susceptibility to Substance dependence, Nicotine 1.10 times for heterozygotes (CT) and 1.90 times for homozygotes (TT) {{PMID|17135278|OA=1
}}

rs951266 increases susceptibility to Substance dependence, Nicotine 1.39 times for heterozygotes (CT) and 1.97 times for homozygotes (TT) {{PMID|18385739}}

[http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1000125 plos] Risk Factors for Age-Dependent Nicotine Addiction

{{PMID|17373692|OA=1
}} No evidence for association between 19 cholinergic genes and bipolar disorder.

{{PMID|18227835|OA=1
}} Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking.

{{PMID|18618000|OA=1
}} A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction.

{{PMID|18759969|OA=1
}} In search of causal variants: refining disease association signals using cross-population contrasts.

{{PMID|19330903|OA=1
}} Gene by smoking interaction in hypertension: identification of a major quantitative trait locus on chromosome 15q for systolic blood pressure in Mexican-Americans.

{{PMID|19443489|OA=1
}} Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5.

{{PMID|19706762|OA=1
}} The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.

{{PMID|20808433|OA=1
}} Associations of variants in CHRNA5/A3/B4 gene cluster with smoking behaviors in a Korean population.

{{PMID Auto
|PMID=23196875
|Title=Variants in the 15q25 gene cluster are associated with risk for schizophrenia and bipolar disorder
|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Affy500k}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}