{{Rsnum
|rsid=9536314
|Gene=KL
|Chromosome=13
|position=33054001
|Orientation=plus
|ReferenceAllele=T
|MissenseAllele=G
|GMAF=0.1304
|Gene_s=KL
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
}}
{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 2.7 | 28.3 | 69.0
| HCB | 0.0 | 0.0 | 100.0
| JPT | 0.0 | 0.0 | 100.0
| YRI | 0.7 | 30.1 | 69.2
| ASW | 5.3 | 28.1 | 66.7
| CHB | 0.0 | 0.0 | 100.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 2.0 | 27.7 | 70.3
| LWK | 1.8 | 40.0 | 58.2
| MEX | 1.8 | 15.8 | 82.5
| MKK | 4.5 | 34.2 | 61.3
| TSI | 1.0 | 29.7 | 69.3
| HapMapRevision=28
}}{{Venter SNP
|rsid=9536314
|allele=G
|frequency=
|uid=1103649192249
|type=heterozygous_SNP
|hugo=KL
|ensembl gene=ENSG00000133116
|ensembl transcript=ENST00000255481
|sift=AFFECT FUNCTION
|disease=Defects in KL may be a cause of chronic renal failure complications.
}}

{{ neighbor
| rsid = 9527025
| distance = 55
}}

{{PMID Auto
|PMID=20394945
|Title=Infantile hypercalcemia and hypercalciuria: new insights into a vitamin D-dependent mechanism and response to ketoconazole treatment
}}

{{PMID Auto
|PMID=21565945
|Title=Lack of association of Klotho gene variants with valvular and vascular calcification in Caucasians: a candidate gene study of the Framingham Offspring Cohort
|OA=1
}}

{{PMID Auto
|PMID=16753056
|Title=The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians.
|OA=1
}}

{{PMID Auto
|PMID=18194558
|Title=A hierarchical and modular approach to the discovery of robust associations in genome-wide association studies from pooled DNA samples.
|OA=1
}}

{{PMID Auto
|PMID=21695423
|Title=Klotho locus, metabolic traits, and serum hemoglobin in hospitalized older patients: a genetic association analysis.
|OA=1
}}

{{GET Evidence
|gene=KL
|aa_change=Phe352Val
|aa_change_short=F352V
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs9536314
|overall_frequency_n=1830
|overall_frequency_d=10758
|overall_frequency=0.170106
|n_genomes=14
|n_genomes_annotated=0
|n_haplomes=17
|n_articles=0
|n_articles_annotated=0
|pph2_score=1.0
|nblosum100=3
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}