{{Rsnum
|rsid=9561778
|Gene=ABCC4
|Chromosome=13
|position=95061461
|Orientation=plus
|GMAF=0.1837
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=ABCC4
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 66.4 | 31.0 | 2.7
| HCB | 51.8 | 38.0 | 10.2
| JPT | 59.3 | 40.7 | 0.0
| YRI | 74.8 | 23.8 | 1.4
| ASW | 68.4 | 31.6 | 0.0
| CHB | 51.8 | 38.0 | 10.2
| CHD | 53.7 | 37.0 | 9.3
| GIH | 70.3 | 24.8 | 5.0
| LWK | 76.1 | 23.9 | 0.0
| MEX | 84.5 | 13.8 | 1.7
| MKK | 78.8 | 20.5 | 0.6
| TSI | 70.6 | 28.4 | 1.0
| HapMapRevision=28
}}[[rs9561778]] is a SNP in the ATP-binding cassette, sub-family C (CFTR/MRP), member 4 [[ABCC4]] gene.

A stepwise case-control study of ~400 [[breast cancer]] Japanese patients receiving [[cyclophosphamide]]-based combination [[chemotherapy]], roughly divided equally between those having or not having serious adverse drug reactions (ADRs), concluded that carriers of [[rs9561778]](T) allele had a ~2x higher risk of ADRs. The ADRs for these patients tended to be gastrointestinal toxicity and leukopenia/neutropenia.{{PMID|19696793}}

{{PharmGKB
|RSID=rs9561778
|Name_s=NM_005845.3:c.3366+1243G>T
|Gene_s=ABCC4
|Feature=
|Evidence=PubMed ID:19696793
|Annotation=Risk or phenotype-associated allele: T. Phenotype: In a stepwise case-control association study of breast cancer patients receiving cyclophosphamide combination therapy, rs9561778 in ABCC4 was associated with cyclophosphamide-induced ADRs. Study size: 403. Study population/ethnicity: Japanese women with breast cancer receiving cyclophosphamide based chemotherapy. Significance metric(s): p = 0.00031; OR = 2.06. Type of association: PK.
|Drugs=cyclophosphamide
|Drug Classes=
|Diseases=Breast Neoplasms; Diarrhea; Leukopenia; Neutropenia
|Curation Level=Curated
|PharmGKB Accession ID=PA165109240
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs9561778
|overall_frequency_n=15
|overall_frequency_d=128
|overall_frequency=0.117188
|n_genomes=12
|n_genomes_annotated=0
|n_haplomes=13
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}