{{Rsnum
|rsid=956868
|Gene=WNK1
|Chromosome=12
|position=881746
|Orientation=plus
|ReferenceAllele=A
|MissenseAllele=C
|GMAF=0.1529
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=WNK1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 1.5 | 21.5 | 76.9
| HCB | 4.4 | 37.8 | 57.8
| JPT | 2.3 | 31.8 | 65.9
| YRI | 1.6 | 19.0 | 79.4
| ASW | 1.8 | 35.7 | 62.5
| CHB | 4.4 | 37.8 | 57.8
| CHD | 0.0 | 0.0 | 0.0
| GIH | 3.0 | 19.2 | 77.8
| LWK | 4.7 | 25.5 | 69.8
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{Venter SNP
|rsid=956868
|allele=C
|frequency=0.108
|uid=1103649345714
|type=heterozygous_SNP
|hugo=WNK1
|ensembl gene=ENSG00000060237
|ensembl transcript=ENST00000315939
|sift=TOLERATED
|disease=Defects in WNK1 are a cause of pseudohypoaldosteronism type II (PHAII) (MIM:145260). PHAII is an autosomal dominant disease characterized by severe hypertension, hyperkalemia, and sensitivity to thiazide diuretics which may result from a chloride shunt in the renal distal nephron.
}}

{{PMID Auto
|PMID=19347040
|Title=Polymorphisms in the WNK1 gene are associated with blood pressure variation and urinary potassium excretion.
|OA=1
}}

{{PMID Auto
|PMID=19584173
|Title=Kininogen gene (KNG) variation has a consistent effect on aldosterone response to antihypertensive drug therapy: the GERA study.
|OA=1
}}

{{GET Evidence
|gene=WNK1
|aa_change=Thr809Pro
|aa_change_short=T809P
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs956868
|n_genomes=1
|n_genomes_annotated=0
|n_haplomes=2
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|genetests_testable=Y
|nblosum100=4
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | Illumina Human 1M}}