{{Rsnum
|rsid=9594738
|Chromosome=13
|position=42378009
|Orientation=plus
|GMAF=0.32
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 27.4 | 55.8 | 16.8
| HCB | 78.7 | 19.1 | 2.2
| JPT | 86.6 | 12.5 | 0.9
| YRI | 59.2 | 34.7 | 6.1
| ASW | 59.6 | 36.8 | 3.5
| CHB | 78.7 | 19.1 | 2.2
| CHD | 77.8 | 20.4 | 1.9
| GIH | 44.6 | 49.5 | 5.9
| LWK | 55.0 | 40.4 | 4.6
| MEX | 43.1 | 41.4 | 15.5
| MKK | 31.4 | 45.5 | 23.1
| TSI | 25.5 | 55.9 | 18.6
| HapMapRevision=28
}}{{Report GE
|PubMed=18445777
|Source=journal
|AffyProbeset=SNP_A-1816202
|AffyOrientation=same
|AlleleA=C
|AlleleB=T
|onGW5=
|rsid=9594738
|ancestral=C
|RiskPopulation=Caucasian
|RiskAllele=T
|CaseFreq=0.56
|ControlFreq=
|OddsRatioHet=
|OddsRatioHom=
|OddsRatioAll=-
|Disease=Bone mineral density, lower
|DiseaseSymbol=BMD-L
}}

rs9594738 increases susceptibility to Bone mineral density variations, lower for carriers of the T allele {{PMID|18445777}}

{{GWAS Summary
|SNP=rs9594738
|PubMedID=18445777
|Condition=Bone mineral density (hip)
|Gene=RANKL
|Risk Allele=T
|pValue=2.00E-008
|OR=0.1
|95CI=0.06-0.13) SD decreas
}}

{{omim
|desc=BONE MINERAL DENSITY QUANTITATIVE TRAIT LOCUS 9; BMND9
|id=612110
|rsnum=9594738
}}

{{PharmGKB
|RSID=rs9594738
|Name_s=
|Gene_s=FABP3P2
|Feature=
|Evidence=PubMed ID:17537913
|Annotation=Risk or phenotype-associated allele: not stated Phenotype: Using a Quantitative Transmission Disequilibrium Test (QTDT), this variant was significantly associated with etoposide toxicity based upon IC50 values in cell lines from 30 parent-child trios. Study size: 176. Study population/ethnicity: 87 European descent Caucasians and 89 Yorubans. Significance metric(s): p = 0.00001. Type of association: FA; GN.
|Drugs=etoposide
|Drug Classes=
|Diseases=Drug Toxicity
|Curation Level=Curated
|PharmGKB Accession ID=PA165109377
}}

{{PharmGKB
|RSID=rs9594738
|Name_s=
|Gene_s=FABP3P2
|Feature=
|Evidence=PubMed ID:18445777; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Multiple Genetic Loci for Bone Mineral Density and Fractures (Initial Sample Size: 5,861 individuals; Replication Sample Size: 7,925 individuals; Risk Allele: rs9594738-T). This variant is associated with Bone mineral density (hip).
|Drugs=
|Drug Classes=
|Diseases=Bone Diseases; Bone Diseases, Metabolic; Fractures, Bone
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356562
}}
{{PMID Auto
|PMID=21124946
|Title=Genome-Wide Association Meta-Analysis of Cortical Bone Mineral Density Unravels Allelic Heterogeneity at the RANKL Locus and Potential Pleiotropic Effects on Bone
|OA=1
}}

{{PMID Auto GWAS
|PMID=21533022
|Trait=None
|Title=Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk.
|RiskAllele=T
|Pval=0.000004
|OR=0.1500
|ORtxt=[NR] unit increase
|OA=1
}}

{{PMID Auto
|PMID=21760914
|Title=Pathway-based association analyses identified TRAIL pathway for osteoporotic fractures
|OA=1
}}

{{PMID Auto
|PMID=22022476
|Title=Common genetic variants are associated with accelerated bone mineral density loss after hematopoietic cell transplantation
|OA=1
}}

{{PMID Auto
|PMID=22370887
|Title=Are bone mineral density loci associated with hip osteoporotic fractures? A validation study on previously reported genome-wide association loci in a Chinese population
|OA=1
}}

{{PMID Auto
|PMID=19181680
|Title=Common variants in the region around Osterix are associated with bone mineral density and growth in childhood.
|OA=1
}}

{{PMID Auto
|PMID=20072603
|Title=Genome-wide association study identifies ALDH7A1 as a novel susceptibility gene for osteoporosis.
|OA=1
}}

{{PMID Auto
|PMID=20534768
|Title=OPG and RANK polymorphisms are both associated with cortical bone mineral density: findings from a metaanalysis of the Avon longitudinal study of parents and children and gothenburg osteoporosis and obesity determinants cohorts.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs9594738
|overall_frequency_n=36
|overall_frequency_d=128
|overall_frequency=0.28125
|n_genomes=24
|n_genomes_annotated=0
|n_haplomes=27
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23744843
|Title=Analyses of RANK and RANKL in the post-GWAS context: functional evidence of vitamin D stimulation through a RANKL distal region
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Affy500k}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}