{{Rsnum
|rsid=961253
|Chromosome=20
|position=6423634
|Orientation=plus
|GMAF=0.2874
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 17.7 | 45.1 | 37.2
| HCB | 0.0 | 13.1 | 86.9
| JPT | 1.8 | 30.1 | 68.1
| YRI | 8.8 | 50.3 | 40.8
| ASW | 19.3 | 36.8 | 43.9
| CHB | 0.0 | 13.1 | 86.9
| CHD | 0.9 | 9.2 | 89.9
| GIH | 12.9 | 39.6 | 47.5
| LWK | 16.5 | 45.9 | 37.6
| MEX | 6.9 | 50.0 | 43.1
| MKK | 25.8 | 47.7 | 26.5
| TSI | 15.7 | 43.1 | 41.2
| HapMapRevision=28
}}[http://www.nature.com/ng/journal/v40/n12/abs/ng.262.html nature] [[colorectal cancer]] [[rs961253]]; P = 2.0 times 10-10

{{PMID Auto GWAS
|PMID=19011631
|Trait=Colorectal cancer
|Title=Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer
|RiskAllele=A
|Pval=2E-10
|OR=1.12
|ORtxt=[1.08-1.16]
|OA=1
}}

{{omim
|desc=COLORECTAL CANCER, SUSCEPTIBILITY TO, 11; CRCS11
|id=612592
|rsnum=961253
}}

{{PharmGKB
|RSID=rs961253
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19011631; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. (Initial Sample Size: 1,902 cases, 1,929 controls; Replication Sample Size: 4,878 cases, 4,914 controls); (Region: 20p12.3; Reported Gene(s): Intergenic; Risk Allele: rs961253-A); (p-value= 0.0000000002).This variant is associated with Colorectal cancer.
|Drugs=
|Drug Classes=
|Diseases=Colorectal Neoplasms
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740333
}}

{{PMID Auto
|PMID=20530476
|Title=Risk of Genome-Wide Association Study-Identified Genetic Variants for Colorectal Cancer in a Chinese Population
}}

{{PharmGKB
|RSID=rs961253
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19011631
|Annotation=A meta-analysis of two GWA studies identified this variant at 20p12.3 as a risk locus for colorectal cancer.
|Drugs=
|Drug Classes=
|Diseases=Colorectal Neoplasms
|Curation Level=Curated
|PharmGKB Accession ID=PA162360105
}}
{{PMID Auto
|PMID=21119214
|Title=Colorectal Cancer Susceptibility Loci in a Population-Based Study: Associations with Morphological Parameters
|OA=1
}}

{{PMID Auto
|PMID=22367214
|Title=Characterization of gene-environment interactions for colorectal cancer susceptibility loci
|OA=1
}}

{{PMID Auto
|PMID=22505654
|Title=GWAS-identified colorectal cancer susceptibility loci associated with clinical outcomes
}}

{{PMID Auto
|PMID=22509336
|Title=The SNP rs961253 in 20p12.3 Is Associated with Colorectal Cancer Risk: A Case-Control Study and a Meta-Analysis of the Published Literature
|OA=1
}}

{{PMID Auto
|PMID=19639606
|Title=Correcting "winner's curse" in odds ratios from genomewide association findings for major complex human diseases.
|OA=1
}}

{{PMID Auto
|PMID=20501757
|Title=Low-penetrance susceptibility variants in familial colorectal cancer.
|OA=1
}}

{{PMID Auto
|PMID=20648012
|Title=Association studies on 11 published colorectal cancer risk loci.
|OA=1
}}

{{PMID Auto
|PMID=21071539
|Title=Generalizability and epidemiologic characterization of eleven colorectal cancer GWAS hits in multiple populations.
|OA=1
}}

{{PMID Auto
|PMID=21314996
|Title=Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci.
|OA=1
}}

{{PMID Auto
|PMID=22045029
|Title=Relationship between 16 susceptibility loci and colorectal cancer phenotype in 3146 patients.
}}

{{PMID Auto
|PMID=22235025
|Title=Susceptibility genetic variants associated with early-onset colorectal cancer.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs961253
|overall_frequency_n=42
|overall_frequency_d=128
|overall_frequency=0.328125
|n_genomes=28
|n_genomes_annotated=0
|n_haplomes=35
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23359760
|Title=Single-nucleotide polymorphism associations for colorectal cancer in southern chinese population
|OA=1
}}

{{PMID Auto
|PMID=23537995
|Title=Evidence of Colorectal Cancer Risk Associated Variant Lys25Ser in the proximity of Human Bone Morphogenetic Protein 2
}}

{{PMID Auto
|PMID=22848671
|Title=Association of eleven common, low-penetrance colorectal cancer susceptibility genetic variants at six risk loci with clinical outcome.
|OA=1
}}

{{PMID Auto
|PMID=22999960
|Title=Much of the genetic risk of colorectal cancer is likely to be mediated through susceptibility to adenomas.
|OA=1
}}

{{PMID Auto
|PMID=23161572
|Title=BMP2/BMP4 colorectal cancer susceptibility loci in northern and southern European populations.
}}

{{PMID Auto
|PMID=23434150
|Title=Are the common genetic variants associated with colorectal cancer risk for DNA mismatch repair gene mutation carriers?
|OA=1
}}

{{PMID Auto
|PMID=24875374
|Title=Variation in the Association Between Colorectal Cancer Susceptibility Loci and Colorectal Polyps by Polyp Type
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}