{{Rsnum
|rsid=964184
|Gene=ZNF259
|Chromosome=11
|position=116778201
|Orientation=plus
|GMAF=0.2002
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=ZPR1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 76.8 | 22.3 | 0.9
| HCB | 59.9 | 36.5 | 3.6
| JPT | 41.6 | 49.6 | 8.8
| YRI | 64.6 | 32.7 | 2.7
| ASW | 70.2 | 28.1 | 1.8
| CHB | 59.9 | 36.5 | 3.6
| CHD | 59.6 | 37.6 | 2.8
| GIH | 66.3 | 29.7 | 4.0
| LWK | 60.0 | 37.3 | 2.7
| MEX | 50.0 | 44.8 | 5.2
| MKK | 62.8 | 34.6 | 2.6
| TSI | 67.6 | 24.5 | 7.8
| HapMapRevision=28
}}
{{PMID Auto GWAS
|PMID=19060906
|Trait=HDL cholesterol
|Title=Common variants at 30 loci contribute to polygenic dyslipidemia
|RiskAllele=G
|Pval=1E-12
|OR=0.17
|ORtxt=[0.11-0.23] SD decrease
|OA=1
}}

{{PharmGKB
|RSID=rs964184
|Name_s=
|Gene_s=BUD13, ZNF259
|Feature=
|Evidence=PubMed ID:19060906; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Common variants at 30 loci contribute to polygenic dyslipidemia. (Initial Sample Size: 19,840 individuals; Replication Sample Size: Up to 20,623 individuals); (Region: 11q23.3; Reported Gene(s): APOA1, APOC3, APOA4, APOA5; Risk Allele: rs964184-G); (p-value= 0.000000000001).This variant is associated with HDL cholesterol.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740243
}}

{{PMID Auto GWAS
|PMID=20657596
|Trait=Hypertriglyceridemia
|Title=Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia
|RiskAllele=G
|Pval=5E-24
|OR=3.28
|ORtxt=[2.61-4.14]
|OA=1
}}
{{PMID Auto GWAS
|PMID=20864672
|Trait=None
|Title=Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease
|RiskAllele=G
|Pval=2E-11
|OR=0.03
|ORtxt=[0.02-0.04] unit decrease
|OA=1
}}

{{PharmGKB
|RSID=rs964184
|Name_s=
|Gene_s=BUD13, ZNF259
|Feature=
|Evidence=PubMed ID:19060906; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Common variants at 30 loci contribute to polygenic dyslipidemia. (Initial Sample Size: 19,840 individuals; Replication Sample Size: Up to 20,623 individuals); (Region: 11q23.3; Reported Gene(s): APOA1, APOC3, APOA4, APOA5; Risk Allele: rs964184-G); (p-value= 4E-62).This variant is associated with Triglycerides.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740266
}}

The [[rs964184(G;G)]] genotype is associated with [[hypertriglyceridemia]]. {{PMID|20657596|OA=1
}}

{{PMID Auto GWAS
|PMID=21378990
|Trait=None
|Title=Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
|RiskAllele=G
|Pval=1E-17
|OR=1.1300
|ORtxt=[1.10-1.16]
|OA=1
}}

{{PMID Auto GWAS
|PMID=21729881
|Trait=None
|Title=Genome-wide association study identifies common variants associated with circulating vitamin E levels.
|RiskAllele=G
|Pval=8E-12
|OR=0.0400
|ORtxt=[0.02-0.06] unit increase
|OA=1
}}

{{PMID Auto GWAS
|PMID=22003152
|Trait=None
|Title=Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies.
|RiskAllele=C
|Pval=8E-11
|OR=0.0320
|ORtxt=None
|OA=1
}}

{{PMID Auto GWAS
|PMID=20686565
|Trait=None
|Title=Biological, clinical and population relevance of 95 loci for blood lipids.
|RiskAllele=G
|Pval=0
|OR=16.9500
|ORtxt=None
|OA=1
}}

{{PMID Auto
|PMID=22399527
|Title=Genome-Wide Screen for Metabolic Syndrome Susceptibility Loci Reveals Strong Lipid Gene Contribution but No Evidence for Common Genetic Basis for Clustering of Metabolic Syndrome Traits
|OA=1
}}

{{PMID Auto
|PMID=21889769
|Title=Variants in the APOA5 gene region and the response to combination therapy with statins and fenofibric acid in a randomized clinical trial of individuals with mixed dyslipidemia
}}

{{PMID Auto
|PMID=22437554
|Title=Genome-Wide Association Study Identifies Three Common Variants Associated with Serologic Response to Vitamin E Supplementation in Men.
|OA=1
}}

{{PMID Auto
|PMID=22567092
|Title=MultiPhen: Joint Model of Multiple Phenotypes Can Increase Discovery in GWAS
|OA=1
}}

{{PMID Auto GWAS
|PMID=22359512
|Trait=None
|Title=Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
|RiskAllele=
|Pval=2E-10
|OR=1.0000
|ORtxt=None
|OA=1
}}

{{PMID Auto
|PMID=19656773
|Title=A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia.
|OA=1
}}

{{PMID Auto
|PMID=19951432
|Title=Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.
|OA=1
}}

{{PMID Auto
|PMID=20160193
|Title=Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples.
|OA=1
}}

{{PMID Auto
|PMID=20339536
|Title=Genome-wide association of lipid-lowering response to statins in combined study populations.
|OA=1
}}

{{PMID Auto
|PMID=20385826
|Title=Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs964184
|overall_frequency_n=108
|overall_frequency_d=128
|overall_frequency=0.84375
|n_genomes=54
|n_genomes_annotated=0
|n_haplomes=88
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23119086
|Title=Variants Identified in a GWAS Meta-Analysis for Blood Lipids Are Associated with the Lipid Response to Fenofibrate
|OA=1
}}

{{PMID Auto
|PMID=23404648
|Title=An association study between genetic polymorphisms related to lipoprotein-associated phospholipase A(2) and coronary heart disease
|OA=1
}}

{{PMID Auto GWAS
  |PMID=22916037
  |Trait=Metabolite levels
  |Title=Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
  |RiskAllele=
  |Pval=8E-20
  |OR=NR
  |ORtxt=NR
  |OA=1
}}

{{PMID Auto GWAS
  |PMID=23505323
  |Trait=Hypertriglyceridemia
  |Title=Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
  |RiskAllele=
  |Pval=5E-35
  |OR=1.77
  |ORtxt=[1.67-1.87]
  |OA=1
}}

{{PMID Auto GWAS
  |PMID=23726366
  |Trait=Triglycerides
  |Title=Genome-wide Characterization of Shared and Distinct Genetic Components that Influence Blood Lipid Levels in Ethnically Diverse Human Populations.
  |RiskAllele=G
  |Pval=4E-33
  |OR=.16
  |ORtxt=[NR] unit increase
  |OA=1
}}

{{PMID Auto
|PMID=24623848
|Title=Genetic Variants Reflecting Higher Vitamin E Status in Men Are Associated with Reduced Risk of Prostate Cancer
}}

{{PMID Auto
|PMID=22914552
|Title=APOA5 genotype modulates 2-y changes in lipid profile in response to weight-loss diet intervention: the Pounds Lost Trial.
|OA=1
}}

{{PMID Auto
|PMID=23832694
|Title=Common genetic variants associated with lipid profiles in a Chinese pediatric population.
}}

{{PMID Auto GWAS
  |PMID=24262325
  |Trait=Coronary artery disease or ischemic stroke
  |Title=Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
  |RiskAllele=
  |Pval=2E-5
  |OR=NR
  |ORtxt=NR
  }}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}