{{Rsnum
|rsid=9642880
|Chromosome=8
|position=127705823
|Orientation=plus
|GMAF=0.4963
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 35.4 | 44.2 | 20.4
| HCB | 46.7 | 43.1 | 10.2
| JPT | 53.6 | 35.7 | 10.7
| YRI | 3.4 | 35.4 | 61.2
| ASW | 7.0 | 33.3 | 59.6
| CHB | 46.7 | 43.1 | 10.2
| CHD | 49.5 | 34.9 | 15.6
| GIH | 18.8 | 38.6 | 42.6
| LWK | 1.8 | 34.5 | 63.6
| MEX | 19.0 | 55.2 | 25.9
| MKK | 9.6 | 42.9 | 47.4
| TSI | 29.4 | 53.9 | 16.7
| HapMapRevision=28
}}{{CPMC SNP
|link=https://cpmc.coriell.org/v/Report/BladderCancer
}}[[rs9642880]] is a SNP located in chromosome region [[8q24]], a region that has been linked to prostate, breast, and colon [[cancer]].

A study ultimately totaling over 4,000 [[bladder cancer]] patients of European ancestry (and 40,000 controls) concluded that individuals carrying two copies of [[rs9642880]](T) were at 1.49x increased risk (allele-specific odds ratio = 1.22, p = 9 x 10e-12) for the disease. This SNP was not associated, however, with risk for prostate, breast, or colon cancer.{{doi|10.1038/ng.229}}

Another study in Chinese populations found similar results in regard to bladder cancer. {{PMID|19369583}}

{{PMID|18794855}} rs9642880(T;T) estimated risk of developing 1.49 times that of noncarriers. 1,803 urinary bladder cancer cases and 34,336 controls. No association with prostate, colorectal and breast cancers.

{{PMID|19801959}} In contrast to [[GSTM1]] SNPs, the [[rs9642880]](T) was only associated with increased risk for bladder cancer in cases not selected based on exposure to bladder carcinogens such as aromatic amines and polycyclic aromatic hydrocarbons, based on an analysis of 515 bladder cancer cases and 893 controls where the quality and quantity of occupational exposure to bladder carcinogens was documented.

{{GWAS Summary
|SNP=rs9642880
|PubMedID=18794855
|Condition=Urinary bladder cancer
|Gene=MYC, BC042052
|Risk Allele=T
|pValue=9.00E-012
|OR=1.22
|95CI=1.15-1.29
}}

{{omim
|desc=BLADDER CANCER
|id=109800
|rsnum=9642880
}}

{{PharmGKB
|RSID=rs9642880
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18794855; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Sequence variant on 8q24 confers susceptibility to urinary bladder cancer (Initial Sample Size: 1,803 cases, 34,336 controls; Replication Sample Size: 2,165 cases, 3,800 controls; Risk Allele: rs9642880-T). This variant is associated with Urinary bladder cancer.
|Drugs=
|Drug Classes=
|Diseases=Urinary Bladder Neoplasms
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356571
}}

{{PMID Auto GWAS
|PMID=20348956
|Trait=Urinary bladder cancer
|Title=A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer
|RiskAllele=T
|Pval=7E-12
|OR=1.21
|ORtxt=[1.15-1.28]
|OA=1
}}

{{PharmGKB
|RSID=rs9642880
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18794855
|Annotation=This variant is associated with increased risk for urinary bladder cancer. It is located on Chromosome 8q24 and 30 KB upstream of MYC.
|Drugs=
|Drug Classes=
|Diseases=Urinary Bladder Neoplasms; Urologic Neoplasms
|Curation Level=Curated
|PharmGKB Accession ID=PA162355811
}}
{{PMID Auto
|PMID=21051319
|Title=Risk of Urinary Bladder Cancer is Associated with 8q24 Variant rs9642880[T]: Results from the Los Angeles-Shanghai Case-Control Study
|OA=1
}}
{{PMID Auto GWAS
|PMID=20972438
|Trait=None
|Title=A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
|RiskAllele=T
|Pval=2E-18
|OR=1.2100
|ORtxt=[1.16-1.27]
|OA=1
}}

{{PMID Auto
|PMID=20065031
|Title=Upregulation of c-MYC in cis through a large chromatin loop linked to a cancer risk-associated single-nucleotide polymorphism in colorectal cancer cells.
|OA=1
}}

{{PMID Auto
|PMID=22177160
|Title=Genetic variability in 8q24 confers susceptibility to urothelial carcinoma of the upper urinary tract and is linked with patterns of disease aggressiveness at diagnosis.
}}

{{PMID Auto
|PMID=23053209
|Title=Genetic polymorphisms on 8q24.1 and 4p16.3 are not linked with urothelial carcinoma of the bladder in contrast to their association with aggressive upper urinary tract tumours
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs9642880
|overall_frequency_n=73
|overall_frequency_d=128
|overall_frequency=0.570312
|n_genomes=44
|n_genomes_annotated=0
|n_haplomes=66
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=22994575
|Title=Bladder cancer survival in a former industrial area in Saxony-Anhalt, Germany
}}

{{PMID Auto
|PMID=23284801
|Title=Distinct SNP combinations confer susceptibility to urinary bladder cancer in smokers and non-smokers
|OA=1
}}

{{PMID Auto GWAS
  |PMID=24163127
  |Trait=Bladder cancer
  |Title=Genome-wide association study identifies multiple loci associated with bladder cancer risk.
  |RiskAllele=T
  |Pval=4E-38
  |OR=1.24
  |ORtxt=[1.20-1.28]
  }}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}