{{Rsnum
|rsid=9652490
|Chromosome=15
|position=77671545
|Orientation=plus
|GMAF=0.2759
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene=LINGO1
|Gene_s=LINGO1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 67.3 | 25.7 | 7.1
| HCB | 54.0 | 34.3 | 11.7
| JPT | 45.9 | 47.7 | 6.3
| YRI | 24.1 | 45.5 | 30.3
| ASW | 35.1 | 47.4 | 17.5
| CHB | 54.0 | 34.3 | 11.7
| CHD | 64.8 | 33.3 | 1.9
| GIH | 66.3 | 29.7 | 4.0
| LWK | 36.7 | 38.5 | 24.8
| MEX | 78.9 | 19.3 | 1.8
| MKK | 39.1 | 48.1 | 12.8
| TSI | 61.8 | 34.3 | 3.9
| HapMapRevision=28
}}[[rs9652490]] is a SNP in the [[LINGO1]] gene. Note: it is unclear why one set of authors report the risk allele for essential tremors to be (G), while the others just as clearly report the risk allele to be (A).

A follow-up case-control study replicated the original association of [[rs9652490]](A;A) to an ~2x increased risk for [[Parkinson's disease]], but also found the same risk for [[essential tremor]] (ET), thus linking the two diseases. The ET study was based on ~300 patients.{{PMID|19720553|OA=1
}}

[http://blog.23andme.com/2009/02/02/snpwatch-study-identifies-genetic-variant-associated-with-risk-for-essential-tremor/ 23andMe blog] "In a combined analysis of 752 subjects with essential tremor from Iceland, Austria, Germany and the United States and 15,797 controls, Stefansson et al found that the G version of rs9652490 in the LINGO1 gene is associated with increased odds of the condition. Carrying one G increases the odds of essential tremor by 1.55 times compared to two As. The approximately 5% of the population with European ancestry with two Gs has 2.40 times increased odds."

{{PMID|20957646}} Finds no evidence that [[rs9652490]] is associated with [[Parkinson's disease]] in a Chinese population, or, based on a meta-analysis. 

{{PMID Auto GWAS
|PMID=19182806
|Trait=Essential tremor
|Title=Variant in the sequence of the LINGO1 gene confers risk of essential tremor
|RiskAllele=G
|Pval=1E-9
|OR=1.55
|ORtxt=[1.35-1.79]
|OA=1
}}

{{omim
|desc=TREMOR, HEREDITARY ESSENTIAL, 1; ETM1
|id=190300
|rsnum=9652490
}}
{{PMID Auto
|PMID=19720553
|Title=LINGO1 rs9652490 is associated with essential tremor and Parkinson disease
|OA=1
}}
{{PMID Auto
|PMID=19908305
|Title=Role of LINGO1 polymorphisms in Parkinson's disease
|OA=1
}}

{{PharmGKB
|RSID=rs9652490
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19182806; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Variant in the sequence of the LINGO1 gene confers risk of essential tremor. (Initial Sample Size: 452 cases, 14,378 controls; Replication Sample Size: 300 cases, 1,419 controls); (Region: 15q24.3; Reported Gene(s): LINGO1; Risk Allele: rs9652490-G); (p-value= 0.000000001).This variant is associated with Essential tremor.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740005
}}

{{PMID Auto
|PMID=20117178
|Title=Analysis of LINGO1 (rs9652490) polymorphism in sporadic Parkinson's disease in a Polish population, and a meta-analysis
}}

{{PMID Auto
|PMID=20310002
|Title=LINGO1 polymorphisms are associated with essential tremor in Europeans
}}
{{PMID Auto
|PMID=20951767
|Title=LINGO1 rs9652490 variant in Parkinson disease patients
}}

{{PMID Auto
|PMID=21264305
|Title=LINGO1 Variants in the French-Canadian Population
|OA=1
}}

{{PMID Auto
|PMID=22166413
|Title=Genetics of essential tremor
}}

{{PMID Auto
|PMID=22710005
|Title=Genetic variation in LINGO-1 (rs9652490) and risk of Parkinson's disease: twelve studies and a meta-analysis
}}

{{PMID Auto
|PMID=20369022
|Title=Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations.
|OA=1
}}

{{PMID Auto
|PMID=20369371
|Title=LINGO1 and LINGO2 variants are associated with essential tremor and Parkinson disease.
|OA=1
}}

{{PMID Auto
|PMID=20372186
|Title=Replication of the LINGO1 gene association with essential tremor in a North American population.
|OA=1
}}

{{PMID Auto
|PMID=20600614
|Title=Screening for two SNPs of LINGO1 gene in patients with essential tremor or sporadic Parkinson's disease in Chinese population.
}}

{{PMID Auto
|PMID=21158743
|Title=Analysis of Lingo1 variant in sporadic and familial essential tremor among Asians.
}}

{{PMID Auto
|PMID=21207446
|Title=LINGO1 gene analysis in Parkinson's disease phenotypes.
}}

{{PMID Auto
|PMID=21219542
|Title=Lack of association of LINGO1 rs9652490 and rs11856808 SNPs with familial essential tremor.
}}

{{PMID Auto
|PMID=21955595
|Title=LINGO1 rs9652490 and rs11856808 are not associated with the risk of Parkinson's disease: results of a meta-analysis.
}}

{{PMID Auto
|PMID=22425540
|Title=LINGO1 and risk for essential tremor: results of a meta-analysis of rs9652490 and rs11856808.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs9652490
|overall_frequency_n=47
|overall_frequency_d=126
|overall_frequency=0.373016
|n_genomes=32
|n_genomes_annotated=0
|n_haplomes=41
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23574883
|Title=LINGO1 rs9652490 and rs11856808 polymorphisms are not associated with risk for multiple sclerosis
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}