{{Rsnum
|rsid=975278
|Gene=SERPINE2
|Chromosome=2
|position=223982990
|Orientation=minus
|GMAF=0.3085
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=SERPINE2
}}[[rs975278]] is a SNP in the [[SERPINE2]] gene.

A study involving 1,335 consecutive autopsies of elderly Japanese people found [[emphysema]] of more than moderate degree in 189 subjects and among 12 examined SNPs, found that only [[rs975278]] was positively associated (with emphysema).[[rs975278]](A;A) individuals were associated with emphysema (odds ratio 1.54, CI: 1.02-2.30, p = 0.037) and the association was more prominent in smokers (odds ratio 2.02, CI: 1.29-3.15, p = 0.002).{{PMID|21067581|OA=1
}}

{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 2.7 | 23.0 | 74.3
| HCB | 27.7 | 48.2 | 24.1
| JPT | 34.5 | 46.0 | 19.5
| YRI | 9.5 | 42.9 | 47.6
| ASW | 8.8 | 42.1 | 49.1
| CHB | 27.7 | 48.2 | 24.1
| CHD | 29.4 | 45.0 | 25.7
| GIH | 10.9 | 52.5 | 36.6
| LWK | 10.9 | 34.5 | 54.5
| MEX | 1.7 | 31.0 | 67.2
| MKK | 4.5 | 38.5 | 57.1
| TSI | 3.9 | 31.4 | 64.7
| HapMapRevision=28
}}

{{PMID Auto
|PMID=21611750
|Title=Association of SERPINE2 gene with the risk of chronic obstructive pulmonary disease and spirometric phenotypes in northern Han Chinese population
}}

{{PMID Auto
|PMID=22145704
|Title=SERPINE2 haplotype as a risk factor for panlobular type of emphysema
|OA=1
}}

{{PMID Auto
|PMID=16358219
|Title=The SERPINE2 gene is associated with chronic obstructive pulmonary disease.
|OA=1
}}

{{PMID Auto
|PMID=19017876
|Title=Genetic associations with hypoxemia and pulmonary arterial pressure in COPD.
|OA=1
}}

{{PMID Auto
|PMID=19949669
|Title=SERPINE2 polymorphisms and chronic obstructive pulmonary disease.
|OA=1
}}

{{PMID Auto
|PMID=20233420
|Title=Cluster analysis in severe emphysema subjects using phenotype and genotype data: an exploratory investigation.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}