{{Rsnum
|rsid=975833
|Gene=ADH1A
|Chromosome=4
|position=99280582
|Orientation=plus
|GMAF=0.3815
|Gene_s=ADH1A,SLC3A1
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 9.5 | 42.9 | 47.6
| HCB | 71.1 | 26.7 | 2.2
| JPT | 63.6 | 34.1 | 2.3
| YRI | 11.3 | 33.9 | 54.8
| ASW | 0.0 | 0.0 | 0.0
| CHB | 71.1 | 26.7 | 2.2
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs975833
|Name_s=ADH1A^SNP11
|Gene_s=ADH1A
|Feature=
|Evidence=Web Resource:http://www.pharmgkb.org/search/annotatedGene/adh1a/variant.jsp
|Annotation=This SNP is located in intron 7 of ADH1A. ADH1A^SNP11 was the only SNP examined in ADH1A that showed a tendency towards an association with alcohol dependence in the African American sample.
|Drugs=ethanol
|Drug Classes=
|Diseases=
|Curation Level=In-Depth
|PharmGKB Accession ID=PA161845831
}}

{{PMID Auto
|PMID=16685648
|Title=Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence.
|OA=1
}}

{{PMID Auto
|PMID=17185388
|Title=Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans.
|OA=1
}}

{{PMID Auto
|PMID=17273965
|Title=Evidence of positive selection on a class I ADH locus.
|OA=1
}}

{{PMID Auto
|PMID=19526455
|Title=ADH1A variation predisposes to personality traits and substance dependence.
|OA=1
}}

{{PMID Auto
|PMID=19687126
|Title=A non-synonymous variant in ADH1B is strongly associated with prenatal alcohol use in a European sample of pregnant women.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs975833
|overall_frequency_n=41
|overall_frequency_d=128
|overall_frequency=0.320312
|n_genomes=29
|n_genomes_annotated=0
|n_haplomes=38
|n_articles=0
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}