{{Rsnum
|rsid=983332
|Chromosome=1
|position=87666697
|Orientation=minus
|GMAF=0.2493
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 4.4 | 31.0 | 64.6
| HCB | 9.5 | 41.6 | 48.9
| JPT | 12.4 | 39.8 | 47.8
| YRI | 13.6 | 32.0 | 54.4
| ASW | 5.3 | 38.6 | 56.1
| CHB | 9.5 | 41.6 | 48.9
| CHD | 8.3 | 44.0 | 47.7
| GIH | 5.0 | 27.0 | 68.0
| LWK | 10.0 | 42.7 | 47.3
| MEX | 0.0 | 28.1 | 71.9
| MKK | 12.2 | 55.8 | 32.1
| TSI | 11.8 | 30.4 | 57.8
| HapMapRevision=28
}}

{{GWAS Summary
|SNP=rs983332
|PubMedID=18615156
|Condition=Treatment response to TNF antagonists
|Gene=LMO4
|Risk Allele=A
|pValue=5.00E-006
|OR=NA
|95CI=
|OA=1
}}

{{PharmGKB
|RSID=rs983332
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18615156
|Annotation=This variant is significantly associated with the efficacy of anti-TNF treatment in rheumatoid arthritis (Adjusted P-value: 0.000005; OR: 10.2 (2.6, 59.2)). The study is a genome-wide association study using the Illumina HapMap300 SNP chip on 89 RA patients prospectively followed after beginning of anti-TNF therapy.
|Drugs=adalimumab; etanercept; infliximab
|Drug Classes=
|Diseases=Arthritis, Rheumatoid
|Curation Level=Curated
|PharmGKB Accession ID=PA162928818
}}

{{PharmGKB
|RSID=rs983332
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18615156; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in Rheumatoid Arthritis (Initial Sample Size: 89 cases; Replication Sample Size: NR; Risk Allele: rs983332-A). This variant is associated with Treatment response to TNF antagonists.
|Drugs=
|Drug Classes=
|Diseases=Arthritis, Rheumatoid
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356482
}}

{{PMID Auto
|PMID=20369022
|Title=Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations.
|OA=1
}}

{{PMID Auto
|PMID=20423481
|Title=Lack of replication of genetic predictors for the rheumatoid arthritis response to anti-TNF treatments: a prospective case-only study.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs983332
|overall_frequency_n=28
|overall_frequency_d=126
|overall_frequency=0.222222
|n_genomes=18
|n_genomes_annotated=0
|n_haplomes=21
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}