{{Rsnum
|rsid=9888739
|Gene=ITGAM
|Chromosome=16
|position=31301932
|Orientation=plus
|GMAF=0.2172
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=ITGAM
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 82.1 | 17.0 | 0.9
| HCB | 97.8 | 2.2 | 0.0
| JPT | 100.0 | 0.0 | 0.0
| YRI | 14.3 | 43.5 | 42.2
| ASW | 26.3 | 36.8 | 36.8
| CHB | 97.8 | 2.2 | 0.0
| CHD | 96.3 | 3.7 | 0.0
| GIH | 59.4 | 36.6 | 4.0
| LWK | 14.7 | 42.2 | 43.1
| MEX | 84.5 | 13.8 | 1.7
| MKK | 38.1 | 47.7 | 14.2
| TSI | 69.6 | 29.4 | 1.0
| HapMapRevision=28
}}

The T allele of [[rs9888739]] is associated with higher risk of [[systemic lupus erythematosus]].
 
[http://content.nejm.org/cgi/content/full/NEJMe0800096 NEJM] a combined analysis of the 7380 independent samples generated a maximum combined P=2.02x10â€“26 and an odds ratio of 1.65 for the association between the T allele of [[rs9888739]] and [[lupus]].

{{GWAS Summary
|SNP=rs9888739
|PubMedID=18204446
|Condition=Systemic lupus erythematosus in women
|Gene=ITGAM
|Risk Allele=T
|pValue=2.00E-023
|OR=1.62
|95CI=1.47-1.78
|OA=1
}}

{{PharmGKB
|RSID=rs9888739
|Name_s=
|Gene_s=ITGAM
|Feature=
|Evidence=PubMed ID:18204446; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci (Initial Sample Size: 720 cases, 2,337 controls; Replication Sample Size: 1,846 cases, 1,825 controls; Risk Allele: rs9888739-T).
|Drugs=
|Drug Classes=
|Diseases=Lupus erythematosus; Lupus Erythematosus, Systemic
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356734
}}

{{PMID Auto GWAS
|PMID=21408207
|Trait=None
|Title=Differential Genetic Associations for Systemic Lupus Erythematosus Based on Anti-dsDNA Autoantibody Production
|RiskAllele=T
|Pval=1E-15
|OR=1.8000
|ORtxt=[1.56-2.07]
|OA=1
}}

{{PMID Auto
|PMID=18853133
|Title=Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=19129174
|Title=Evaluation of imputation-based association in and around the integrin-alpha-M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE).
|OA=1
}}

{{PMID Auto
|PMID=19286673
|Title=ITGAM is associated with disease susceptibility and renal nephritis of systemic lupus erythematosus in Hong Kong Chinese and Thai.
|OA=1
}}

{{PMID Auto
|PMID=20629846
|Title=Association of ITGAM polymorphism with systemic lupus erythematosus: a meta-analysis.
}}

{{PMID Auto
|PMID=21379322
|Title=Risk alleles for systemic lupus erythematosus in a large case-control collection and associations with clinical subphenotypes.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs9888739
|overall_frequency_n=37
|overall_frequency_d=128
|overall_frequency=0.289062
|n_genomes=27
|n_genomes_annotated=0
|n_haplomes=34
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}