{{Rsnum
|rsid=9930506
|Gene=FTO
|Chromosome=16
|position=53796553
|Orientation=plus
|GMAF=0.2984
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=FTO
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 25.0 | 53.6 | 21.4
| HCB | 64.0 | 30.9 | 5.1
| JPT | 57.5 | 38.9 | 3.5
| YRI | 65.3 | 31.3 | 3.4
| ASW | 62.5 | 35.7 | 1.8
| CHB | 64.0 | 30.9 | 5.1
| CHD | 63.3 | 30.3 | 6.4
| GIH | 41.6 | 47.5 | 10.9
| LWK | 73.4 | 24.8 | 1.8
| MEX | 55.2 | 43.1 | 1.7
| MKK | 56.3 | 42.4 | 1.3
| TSI | 31.7 | 42.6 | 25.7
| HapMapRevision=28
}}This snp influences [[obesity]] however the most strongly linked neighboring snp is [[rs9939609]]. You probably want that one.

This [http://genetics.plosjournals.org/perlserv/?request=get-document&doi=10.1371%2Fjournal.pgen.0030115.eor plos genetics paper] reports [[rs9930506]] showed the strongest association with [[BMI]] (p = 8.6 *10-7), hip circumference (p = 3.4 * 10-8) and weight (p = 9.1 * 10-7). homozygotes for the rare "G" allele were were 1.3 BMI units heavier than homozygotes for the common "A" allele. 

This SNP did not show any association with [[obesity]], [[type-2 diabetes]] or any other related traits in a study of 3,210 Chinese subjects. Furthermore, the minor allele frequency was much lower in Chinese populations compared to populations of European descent.{{PMID|17959933}}

{{PMID|19148128}} rs9930506 (A;A) showed decreased levels of methylated PPARGC1A in comparison with AG + GG genotypes, suggesting a potential role of promoter PPARGC1A [[methylation]] in metabolic programming.

{{ neighbor
| rsid = 9932754
| distance = 26
}}

{{GWAS Summary
|SNP=rs9930506
|PubMedID=17658951
|Condition=Obesity-related traits
|Gene=FTO
|Risk Allele=G
|pValue=9.00E-007
|OR=0.12
|95CI=NR) SD lower (weight
|OA=1
}}

{{PharmGKB
|RSID=rs9930506
|Name_s=
|Gene_s=FTO
|Feature=
|Evidence=PubMed ID:17658951; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Genome-Wide Association Scan Shows Genetic Variants in the FTO Gene Are Associated with Obesity-Related Traits (Initial Sample Size: 4,741 individuals; Replication Sample Size: 3,205 individuals; Risk Allele: rs9930506-G).
|Drugs=
|Drug Classes=
|Diseases=Obesity
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356680
}}

{{PharmGKB
|RSID=rs9930506
|Name_s=
|Gene_s=FTO
|Feature=
|Evidence=PubMed ID:17658951; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Genome-Wide Association Scan Shows Genetic Variants in the FTO Gene Are Associated with Obesity-Related Traits (Initial Sample Size: 4,741 individuals; Replication Sample Size: 3,205 individuals; Risk Allele: rs9930506-G).
|Drugs=
|Drug Classes=
|Diseases=Obesity
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356681
}}

{{PharmGKB
|RSID=rs9930506
|Name_s=
|Gene_s=FTO
|Feature=
|Evidence=PubMed ID:17658951; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Genome-Wide Association Scan Shows Genetic Variants in the FTO Gene Are Associated with Obesity-Related Traits (Initial Sample Size: 4,741 individuals; Replication Sample Size: 3,205 individuals; Risk Allele: rs9930506-G).
|Drugs=
|Drug Classes=
|Diseases=Obesity
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356679
}}

{{PMID Auto
|PMID=22454631
|Title=Association of FTO Polymorphisms with Early Age of Obesity in Obese Italian Subjects.
|OA=1
}}

{{PMID|18325910|OA=1
}} Genome-wide association scans identified CTNNBL1 as a novel gene for obesity.

{{PMID|18379722|OA=1
}} Variations in the FTO gene are associated with severe obesity in the Japanese.

{{PMID|18469204|OA=1
}} Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians.

{{PMID|18487448|OA=1
}} Common variation in the fat mass and obesity-associated (FTO) gene confers risk of obesity and modulates BMI in the Chinese population.

{{PMID|18599522|OA=1
}} FTO variants are associated with obesity in the Chinese and Malay populations in Singapore.

{{PMID|18647953|OA=1
}} Fat mass-and obesity-associated (FTO) gene variant is associated with obesity: longitudinal analyses in two cohort studies and functional test.

{{PMID|19322589|OA=1
}} Analysis of FTO gene variants with measures of obesity and glucose homeostasis in the IRAS Family Study.

{{PMID|19474294|OA=1
}} Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.

{{PMID|19679263|OA=1
}} Using new tools to define the genetic underpinnings of risky traits associated with coronary artery disease: the SardiNIA study.

{{PMID|20018076|OA=1
}} Tests for candidate-gene interaction for longitudinal quantitative traits measured in a large cohort.

{{PMID|20075150|OA=1
}} Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study.

{{PMID|20442772|OA=1
}} Common SNPs in FTO gene are associated with obesity related anthropometric traits in an island population from the eastern Adriatic coast of Croatia.

{{PMID|20502638|OA=1
}} Risk of type 2 diabetes and obesity is differentially associated with variation in FTO in whites and African-Americans in the ARIC study.

{{PMID|21283731|OA=1
}} FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome.

{{PMID|21688152|OA=1
}} Influence of genomic variation in FTO at 16q12.2, MC4R at 18q22 and NRXN3 at 14q31 genes on breast cancer risk.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs9930506
|overall_frequency_n=46
|overall_frequency_d=126
|overall_frequency=0.365079
|n_genomes=26
|n_genomes_annotated=0
|n_haplomes=32
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=24106974
|Title=Association between fat mass and obesity-associated (FTO) gene and hip fracture susceptibility
}}

{{PMID Auto
|PMID=23103831
|Title=VDR TaqI is associated with obesity in the Greek population.
}}

{{PMID Auto
|PMID=25254029
|Title=Effect of the FTO rs9930506 Polymorphism on the Main Comorbidities of the Cardiorenal Metabolic Syndrome in an Elderly Spanish Cohort
}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}