{{Rsnum
|rsid=997509
|Gene=ENPP1
|Chromosome=6
|position=131846837
|Orientation=plus
|GMAF=0.04178
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=ENPP1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 92.2 | 7.8 | 0.0
| HCB | 100.0 | 0.0 | 0.0
| JPT | 100.0 | 0.0 | 0.0
| YRI | 87.1 | 11.3 | 1.6
| ASW | 0.0 | 0.0 | 0.0
| CHB | 100.0 | 0.0 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{PMID|16936213}} [[rs997509]] increases the risk of [[Type-2 diabetes]] for the obese.

*[[rs997509]] we found a new SNP, rs997509, in intron 1 that is strongly associated with risk of type 2 diabetes in obese individuals.

{{PharmGKB
|RSID=rs997509
|Name_s=
|Gene_s=ENPP1
|Feature=
|Evidence=PubMed ID:18940878
|Annotation=A study of 809 children, 409 obese and 400 lean controls, conclude that the ENPP1 rs997509T allele can predispose obese children to metabolic syndrome and impaired glucose tolerance and that this variant might drive the association between the ENPP1 121Q allele and insulin resistance
|Drugs=
|Drug Classes=
|Diseases=Insulin Resistance; Obesity
|Curation Level=Curated
|PharmGKB Accession ID=PA162411185
}}

{{PMID Auto
|PMID=18719658
|Title=Gender differences in the relationship of ENPP1/PC-1 variants to obesity in a Turkish population.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs997509
|overall_frequency_n=3
|overall_frequency_d=128
|overall_frequency=0.0234375
|n_genomes=1
|n_genomes_annotated=0
|n_haplomes=1
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}