{{Rsnum
|rsid=999737
|Gene=RAD51L1
|Chromosome=14
|position=68567965
|Orientation=plus
|GMAF=0.1088
|Gene_s=RAD51B
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 52.2 | 43.4 | 4.4
| HCB | 99.3 | 0.7 | 0.0
| JPT | 100.0 | 0.0 | 0.0
| YRI | 100.0 | 0.0 | 0.0
| ASW | 96.5 | 3.5 | 0.0
| CHB | 99.3 | 0.7 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 84.2 | 15.8 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 63.8 | 32.8 | 3.4
| MKK | 98.7 | 1.3 | 0.0
| TSI | 59.8 | 39.2 | 1.0
| HapMapRevision=28
}}[http://www.nih.gov/news/health/mar2009/nci-29.htm NIH] rs999737 is located near an interesting gene, RAD51L1, which is in a pathway previously implicated in [[breast cancer]] risk. The protein encoded by this gene interacts directly with those of other genes that are involved in DNA repair and in the exchange of material between strands of DNA.
{{PMID Auto
|PMID=19330030
|Title=A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1).
|OA=1
}}

{{PharmGKB
|RSID=rs999737
|Name_s=
|Gene_s=RAD51L1
|Feature=
|Evidence=PubMed ID:19330030; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: A multistage genome-wide association study in Breast Cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1). (Initial Sample Size: 1,145 cases, 1,142 controls; Replication Sample Size: 8,625 cases, 9,657 controls); (Region: 14q24.1; Reported Gene(s): RAD51L1; Risk Allele: rs999737-C); (p-value= 0.0000002).This variant is associated with Breast Cancer.
|Drugs=
|Drug Classes=
|Diseases=Breast Neoplasms
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164739884
}}

{{omim
|id=114480
|rsnum=999737
}}

{{PMID Auto
|PMID=21791674
|Title=Interactions Between Genetic Variants and Breast Cancer Risk Factors in the Breast and Prostate Cancer Cohort Consortium
|OA=1
}}

{{PMID Auto
|PMID=21852249
|Title=Associations of common variants at 1p11.2 and 14q24.1 (RAD51L1) with breast cancer risk and heterogeneity by tumor subtype: Findings from the Breast Cancer Association Consortium
|OA=1
}}

{{PMID Auto
|PMID=21959381
|Title=Fine mapping of 14q24.1 breast cancer susceptibility locus
}}

{{PMID Auto
|PMID=21593217
|Title=Common alleles at 6q25.1 and 1p11.2 are associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers
|OA=1
}}

{{PMID Auto
|PMID=22313133
|Title=Genetic Variants at 14q24.1 and Breast Cancer Susceptibility: a Fine-Mapping Study in Chinese Women
|OA=1
}}
common variants at 14q24.1 might not be associated with the risk of breast cancer in the Chinese population.
Rs999737 is not a risk allele for Chinese

{{PMID Auto
|PMID=20085711
|Title=Leveraging genetic variability across populations for the identification of causal variants.
|OA=1
}}

{{PMID Auto
|PMID=20146796
|Title=Familial relative risks for breast cancer by pathological subtype: a population-based cohort study.
|OA=1
}}

{{PMID Auto
|PMID=20237344
|Title=Performance of common genetic variants in breast-cancer risk models.
|OA=1
}}

{{PMID Auto
|PMID=21844186
|Title=Common breast cancer susceptibility loci are associated with triple-negative breast cancer.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs999737
|overall_frequency_n=12
|overall_frequency_d=128
|overall_frequency=0.09375
|n_genomes=10
|n_genomes_annotated=0
|n_haplomes=10
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=23535729
  |Trait=Breast cancer
  |Title=Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
  |RiskAllele=C
  |Pval=3E-19
  |OR=1.09
  |ORtxt=[1.06-1.11]
  |OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}